Fascia Layer-A Novel Target for the Application of Biomaterials in Skin Wound Healing

Abstract

As the first barrier of the human body, the skin has been of great concern for its wound healing and regeneration. The healing of large, refractory wounds is difficult to be repaired by cell proliferation at the wound edges and usually requires manual intervention for treatment. Therefore, therapeutic tools such as stem cells, biomaterials, and cytokines have been applied to the treatment of skin wounds. Skin microenvironment modulation is a key technology to promote wound repair and skin regeneration. In recent years, a series of novel bioactive materials that modulate the microenvironment and cell behavior have been developed, showing the ability to efficiently facilitate wound repair and skin attachment regeneration. Meanwhile, our lab found that the fascial layer has an indispensable role in wound healing and repair, and this review summarizes the research progress of related bioactive materials and their role in wound healing.

Keywords: biomaterials; fascia layer; new target; wound healing.

Figure 1

The structure of the skin.

Figure 2

Histological differences between mouse and human skin. Above is a cartoon depiction of the difference between mouse and human skin. This image is a reference image [16]. Below is the histological difference between mouse and human skin, scale bar 500 μm.

Figure 3

The key phases of wound healing.

Figure 4

This image is a reference image [27], fluorescence images of wounds on day 7 of fascia labelling experiment, nuclei (blue), labelled fascia (magenta, green), scare bar: 500 µm (top), 100 µm (bottom).