Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan 30;12(3):1071.
doi: 10.3390/jcm12031071.

Evolution of the Incidence of Oral Cavity Cancers in the Elderly from 1990 to 2018

Alice Renou  1 , Anne-Valérie Guizard  2   3   4 , Emilien Chabrillac  5 , Gautier Defossez  2   6 , Pascale Grosclaude  2   7   8 , Sophie Deneuve  9   10 , Sébastien Vergez  1 , Bénédicte Lapotre-Ledoux  2   11   12 , Sandrine D Plouvier  2   13 , Agnès Dupret-Bories  1 , Francim Network
Affiliations

Evolution of the Incidence of Oral Cavity Cancers in the Elderly from 1990 to 2018

Alice Renou et al. J Clin Med. .

Abstract

Objectives: To describe the evolution of the incidence of oral cavity cancers (OCC) among elderly patients in France between 1990 and 2018 and to compare it to the incidence of other cancers sharing the same main risk factors.

Material and methods: The incidence of cancers in mainland France from 1990 to 2018 was estimated from incidence data observed in every cancer registry of the Francim network. Incidence was modeled by a 2-dimensional penalized spline of age and year of diagnosis, associated with a random effect corresponding to the registry. The elderly population was divided into two groups: 70-79 years old and ≥80 years old.

Results: There was a 72% increase in the number of OCC cases in women over 70 years of age between the periods 1990-1999 and 2010-2018. As for men, there was a stabilization in the number of cases (+2%). Over the same period, for laryngeal and hypopharyngeal cancers, there was a decrease in incidence in elderly men and an increase in elderly women, although less marked than for OCC.

Conclusions: Since the 1990s, the incidence of OCC has been increasing in elderly subjects in France, particularly in women. Population aging and growth or alcohol and tobacco consumption alone do not seem to explain this increase, which is not observed in the same proportions for other upper aerodigestive tract cancer subsites sharing the same main risk factors.

Keywords: elderly; epidemiology; incidence; oral cavity cancer.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Evolution of the incidence rate of the oral cavity, hypopharynx, and larynx cancer in France, between 1990–1999 and 2010–2018, by sex, among subjects aged less than 70 years, 70 to 79 years, and 80 years or more.
Figure 1
Figure 1
Evolution of the incidence rate of the oral cavity, hypopharynx, and larynx cancer in France, between 1990–1999 and 2010–2018, by sex, among subjects aged less than 70 years, 70 to 79 years, and 80 years or more.
Figure 2
Figure 2
Evolution of oral cavity cancer incidence by sex for the “70–79 years” and “80 years or more” age groups (M: men, W: women).
Figure 3
Figure 3
Evolution of age-specific incidence of oral cavity cancers for French men and women. Reprinted with permission from Defossez, G. et al. [1] (p. 39) Copyright 2019, Francim_HCL_SPF_INCa. Available online: https://www.santepubliquefrance.fr/maladies-et-traumatismes/cancers/cancer-du-sein/documents/rapport-synthese/estimations-nationales-de-l-incidence-et-de-la-mortalite-par-cancer-en-france-metropolitaine-entre-1990-et-2018-volume-1-tumeurs-solides-etud (accessed on 5 July 2019).
See this image and copyright information in PMC

References

    1. Defossez G., Le Guyader-Peyrou S., Uhry Z., Grosclaude P., Colonna M., Dantony E., Delafosse P., Molinié F., Woronoff S., Bouvier M., et al. Estimations Nationales de L’Incidence et de La Mortalité par Cancer en France Métropolitaine Entre 1990 et 2018. Volume 1. Santé Publique France; Saint-Maurice, France: 2019. 372p
    1. Paré A., Joly A. Cancers de la cavité buccale: Facteurs de risque et prise en charge. Presse Méd. 2017;46:320–330. doi: 10.1016/j.lpm.2017.01.004. - DOI - PubMed
    1. Guizard A.-V., Lapôtre-Ledoux B., Velten M., Lecoffre C., Lafay L., Coureau G., Mounier M., Trétarre B. Survie des Personnes Atteintes de Cancer en France Métropolitaine 1989–2018—Lèvre, Bouche, Pharynx. Institut National du Cancer; Boulogne-Billancourt, France: 2020. 12p
    1. Jégu J., Colonna M., Daubisse-Marliac L., Trétarre B., Ganry O., Guizard A.-V., Bara S., Troussard X., Bouvier V., Woronoff A.-S., et al. The Effect of Patient Characteristics on Second Primary Cancer Risk in France. BMC Cancer. 2014;14:94. doi: 10.1186/1471-2407-14-94. - DOI - PMC - PubMed
    1. Head and Neck Research Network. Dzioba A., Aalto D., Papadopoulos-Nydam G., Seikaly H., Rieger J., Wolfaardt J., Osswald M., Harris J.R., O’Connell D.A., et al. Functional and Quality of Life Outcomes after Partial Glossectomy: A Multi-Institutional Longitudinal Study of the Head and Neck Research Network. J. Otolaryngol.-Head Neck Surg. 2017;46:56. doi: 10.1186/s40463-017-0234-y. - DOI - PMC - PubMed