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. 2023 Jan 19;28(3):1005.
doi: 10.3390/molecules28031005.

Essential Oils Composition and Biological Activity of Chamaecyparis obtusa, Chrysopogon nigritanus and Lavandula coronopifolia Grown Wild in Sudan

Loai M H Eltayeb  1 , Sakina Yagi  1 , Hanan M M Mohamed  1 , Gokhan Zengin  2 , Mohammad Ali Shariati  3   4 , Maksim Rebezov  5 , Abdullah Ibrahim Uba  6 , Jose Manuel Lorenzo  7   8
Affiliations

Essential Oils Composition and Biological Activity of Chamaecyparis obtusa, Chrysopogon nigritanus and Lavandula coronopifolia Grown Wild in Sudan

Loai M H Eltayeb et al. Molecules. .

Abstract

Generally, there are scant data about the constituents and eventually the biological activity of essential oils (EOs) from aromatic plants that grow naturally in Sudan. The present study aimed to determine the chemical composition, and antioxidant and enzyme inhibitory activities of EO extracted from the fruit of Chamaecyparis obtusa (Siebold and Zucc.) Endl. (family Cupressaceae), root of Chrysopogon nigritanus (Benth.) Veldkampis (family Poaceae) and aerial part of Lavandula coronopifolia Poir (family Lamiaceae). The fruit of C. obtusa contained only monoterpenes, mainly hydrogenated ones, with α-pinene (69.07%) as the major component. Oxygenated sesquiterpenes comprised the highest content of the C. nigritanus root EO with cedr-8-en-15-ol (28.69%) as the major constituent while aerial parts of L. coronopifolia contained both monoterpenes and sesquiterpenes and the oxygenated monoterpene lavandulol (26.56%) as dominant compounds. The EO of the root of C. nigritanus significantly displayed (p < 0.05) the highest anti-DPPH radical, Fe3+- and Cu2+-reducing and metal-chelating activities, while that of C. obtusa fruit significantly exerted (p < 0.05) the best anti-ABTS radical and total antioxidant activity. The two EOs significantly exhibited (p < 0.05) the highest anti-acetylcholinesterase and -butyrylcholinesterase activities, respectively, while EO of L. coronopifolia was the only oil to show a considerable inhibitory effect against the tyrosinase and α-glucosidase enzymes. In conclusion, EOs from these three plants could be natural agents with promising functional properties for food, cosmetics, and pharmaceutical applications.

Keywords: Chamaecyparis obtusa; Chrysopogon nigritanus; Lavandula coronopifolia; antioxidant; chemical profile; enzyme inhibition.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Total ion chromatogram of essential oil from fruit of Chamaecyparis obtusa.
Figure 2
Figure 2
Total ion chromatogram of essential oil from root of Chrysopogon nigritanus.
Figure 3
Figure 3
Total ion chromatogram of essential oil from aerial part of Lavandula stricta.
Figure 4
Figure 4
Binding energy (docking) scores of phytochemicals extracted from Chamaecyparis obtusa, Chrysopogon nigritanus and Lavandula coronopifolia.
Figure 5
Figure 5
Protein–ligand interaction: (A) AChE and α-bisabolol and (B) BChE and cedr-8-en-13-ol. These phytochemical compounds were extracted from C. obtusa, C. nigritanus and L. coronopifolia.
Figure 6
Figure 6
Protein–ligand interaction: (A) tyrosinase and trans-sabinene hydrate, (B) α-amylase and cedr-8-en-15-ol, and (C) α-glucosidase and caryophyllene oxide. These phytochemical compounds were extracted from C. obtusa, C. nigritanus and L. coronopifolia.
See this image and copyright information in PMC

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