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Review
. 2023 Jan 27;28(3):1242.
doi: 10.3390/molecules28031242.

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Yan-Yan Huang  1   2 , Yan-Tong Liang  1   2 , Jia-Min Wu  1   2 , Wei-Tong Wu  1   2 , Xin-Tong Liu  1   2 , Ting-Ting Ye  1   2 , Xiao-Rong Chen  1   2 , Xin-An Zeng  1   2 , Muhammad Faisal Manzoor  1   2 , Lang-Hong Wang  1   2
Affiliations
Review

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Yan-Yan Huang et al. Molecules. .

Abstract

Food allergies are a serious food safety and public health issue. Soybean, dairy, aquatic, poultry, and nut products are common allergens inducing allergic reactions and adverse symptoms such as atopic dermatitis, allergic eczema, allergic asthma, and allergic rhinitis. Probiotics are assumed as an essential ingredient in maintaining intestinal microorganisms' composition. They have unique physiological roles and therapeutic effects in maintaining the mucosal barrier, immune function, and gastrointestinal tract, inhibiting the invasion of pathogenic bacteria, and preventing diarrhea and food allergies. Multiple pieces of evidence reveal a significant disruptive effect of probiotics on food allergy pathology and progression mechanisms. Thus, this review describes the allergenic proteins as an entry point and briefly describes the application of probiotics in allergenic foods. Then, the role of probiotics in preventing and curing allergic diseases by regulating human immunity through intestinal flora and intestinal barrier, modulating host immune active cells, and improving host amino acid metabolism are described in detail. The anti-allergic role of probiotics in the function and metabolism of the gastrointestinal tract has been comprehensively explored to furnish insights for relieving food allergy symptoms and preventing food allergy.

Keywords: food allergy; immunity; intestinal flora; probiotics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Immune mechanism of food allergy.
See this image and copyright information in PMC

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