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. 2023 Jan 19;15(3):524.
doi: 10.3390/nu15030524.

β-Hydroxybutyrate Regulates Activated Microglia to Alleviate Neurodegenerative Processes in Neurological Diseases: A Scoping Review

Siva Shantini Jayashankar  1 , Khaizurin Tajul Arifin  1 , Muhammad Luqman Nasaruddin  1
Affiliations

β-Hydroxybutyrate Regulates Activated Microglia to Alleviate Neurodegenerative Processes in Neurological Diseases: A Scoping Review

Siva Shantini Jayashankar et al. Nutrients. .

Abstract

This scoping review aimed to summarise the effects of the ketone body β-hydroxybutyrate. The review details the revealed pathways and functional properties following its intervention in the context of neurodegenerative diseases. In this study, 5 research publications that met the inclusion and exclusion criteria were shortlisted. Following the intervention, we discovered a tendency of reduced inflammatory status in microglia, as evidenced by lower levels of pro-inflammatory mediators produced, reduced microgliosis in afflicted tissues, and enhanced cognitive functions in neurodegenerative models. We found that there is a significant overlap in the mechanism of action of β-hydroxybutyrate (BHB) via activation of the G-protein-Coupled Receptor 109A (GPR109a) receptor and deactivation of the inflammasome complex. Furthermore, although comparing outcomes can be challenging due to the heterogeneity in the study model, the results we have assembled here were consistent, giving us confidence in the intervention's efficacy. We also discussed new studies where BHB is involved in various roles in regulating inflammation in microglia, allowing for fresh therapeutic targets against neurodegeneration. This brief review provides evidence to support the huge potential of BHB in the treatment of neurodegenerative illnesses.

Keywords: beta-hydroxybutyrate; inflammation; ketogenic diet; microglia; neurodegenerative disease.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. United Nations, Department of Economic and Social Affairs . World Population Ageing. United Nations, Department of Economic and Social Affairs; New York, NY, USA: 2019.
    1. Cai Y., Song W., Li J., Jing Y., Liang C., Zhang L., Zhang X., Zhang W., Liu B., An Y., et al. The landscape of aging. Sci. China Life Sci. 2022;65:2354–2454. - PMC - PubMed
    1. Ridderinkhof K.R., Krugers H.J. Horizons in Human Aging Neuroscience: From Normal Neural Aging to Mental (Fr)Agility. Front. Hum. Neurosci. 2022;16:815759. doi: 10.3389/fnhum.2022.815759. - DOI - PMC - PubMed
    1. Roheger M., Brenning J., Riemann S., Martin A.K., Flöel A., Meinzer M. Progression of socio-cognitive impairment from healthy aging to Alzheimer’s dementia: A systematic review and meta-analysis. Neurosci. Biobehav. Rev. 2022;140:104796. doi: 10.1016/j.neubiorev.2022.104796. - DOI - PubMed
    1. Preston J., Biddell B. The physiology of ageing and how these changes affect older people. Medicine. 2021;49:1–5. doi: 10.1016/j.mpmed.2020.10.011. - DOI

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