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Observational Study
. 2023 Jan 22;15(3):585.
doi: 10.3390/nu15030585.

Serum Fatty Acids Are Associated with a Higher Risk of Ischemic Stroke

Sebastian Andone  1   2   3 , Lénárd Farczádi  4 , Silvia Imre  4   5 , Zoltan Bajko  1   2 , Anca Moțățăianu  1   2 , Smaranda Maier  1   2 , Laura Bărcuțean  1   2 , Rodica Bălașa  1   2   3
Affiliations
Observational Study

Serum Fatty Acids Are Associated with a Higher Risk of Ischemic Stroke

Sebastian Andone et al. Nutrients. .

Abstract

Stroke prevention, a significant public-health concern, begins with recognizing and addressing risk factors. Interventions targeted at modifiable risk factors can effectively prevent ischemic stroke, while Omega-3 fatty acids have been shown to improve stroke outcomes. Our study aimed to investigate the relationship between ischemic-stroke risk factors and fatty acids using a prospective observational study with 274 patients. We collected clinical data on risk factors and measured fatty-acid levels using high-performance liquid chromatography coupled with mass spectrometry. We found that several risk factors, including age, sex, smoking, atrial fibrillation, dyslipidemia, and previous stroke history, had a direct relationship with fatty acids. Of these, smoking had the most significant impact, negatively impacting levels of docosahexaenoic and eicosapentaenoic acid. Conversely, dyslipidemia and atrial fibrillation positively correlated with fatty acids, particularly in female patients and those with recurrent strokes. Age was found to directly correlate with other risk factors and variations in fatty-acid ratios. The stroke rate was higher in males than females before the age of 70, but this trend reversed. Our findings suggest that better management of risk factors, particularly modifiable lifestyle factors, could improve fatty-acid profiles and the balance of Omega-3 and Omega-6 in patients with ischemic stroke.

Keywords: arachidonic acid; docosahexaenoic acid; eicosapentaenoic acid; fatty acids; ischemic stroke; omega-3; omega-6; risk factors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Fatty-acids’ chemical structures.
Figure 2
Figure 2
Omega-3 and Omega-6—sources and pathway.
Figure 3
Figure 3
Pearson correlation graphical representation between age, fatty-acid serum values, and fatty-acid ratios. (* = correlation between).
Figure 4
Figure 4
Risk-factor frequency distribution.
Figure 5
Figure 5
Age-group distribution based on gender.
See this image and copyright information in PMC

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