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. 2023 Jan 24;15(3):603.
doi: 10.3390/nu15030603.

Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study

Xuemin Wang  1 , Dylan M Glubb  1   2 , Tracy A O'Mara  1   2
Affiliations

Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study

Xuemin Wang et al. Nutrients. .

Abstract

Given the strong association between obesity and endometrial cancer risk, dietary factors may play an important role in the development of this cancer. However, observational studies of micro- and macronutrients and their role in endometrial cancer risk have been inconsistent. Clarifying these relationships are important to develop nutritional recommendations for cancer prevention. We performed two-sample Mendelian randomization (MR) to investigate the effects of circulating levels of 15 micronutrients (vitamin A (retinol), folate, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, β-carotene, calcium, copper, iron, magnesium, phosphorus, selenium, and zinc) as well as corrected relative macronutrient intake (protein, carbohydrate, sugar and fat) on risks of endometrial cancer and its subtypes (endometrioid and non-endometrioid histologies). Genetically predicted vitamin C levels were found to be strongly associated with endometrial cancer risk. There was some evidence that genetically predicted relative intake of macronutrients (carbohydrate, sugar and fat) affects endometrial cancer risk. No other significant association were observed. Conclusions: In summary, these findings suggest that vitamin C and macronutrients influence endometrial cancer risk but further investigation is required.

Keywords: Mendelian randomization; carbohydrate; dietary patterns; endometrial cancer; fat; micronutrients; minerals; protein; sugar; vitamins.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Plot of MR sensitivity analyses for dietary that were associated with endometrial cancer (EC) risk by the primary IVW analysis.
See this image and copyright information in PMC

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