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Comparative Study
. 1987 Sep;17(5):393-8.
doi: 10.1111/j.1365-2222.1987.tb02031.x.

Decreased adreno-cortical suppression utilizing the Nebuhaler for inhalation of steroid aerosols

P Prahl  1 , T Jensen
Affiliations
Comparative Study

Decreased adreno-cortical suppression utilizing the Nebuhaler for inhalation of steroid aerosols

P Prahl et al. Clin Allergy. 1987 Sep.

Abstract

The influence on the adrenocortical function of high-dose topical glucocorticoids inhaled via conventional devices and via a Nebuhaler, was studied in ten children with asthma. In patients treated with dosages of beclomethasone dipropionate or budesonide, in excess of 2100 micrograms/1.73 m2 body surface, the 24-h urinary excretion of free cortisol increased when the inhaler device was changed from a conventional one to a Nebuhaler. This suggests a decreased systemic influence of the inhaled glucocorticoids when these were administered via a Nebuhaler.

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