Genetically Engineered Mouse Models Shine New Light on Decades-old Story of Trypsin in Pancreatitis

Bomi Lee¹, Sohail Z Husain², Ilya Gukovsky³

Affiliations

¹ Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Stanford University, Stanford, California.
² Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Stanford University, Stanford, California. Electronic address: Sohail.husain@stanford.edu.
³ Department of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California.

PMID: 36773768
PMCID: PMC10680306
DOI: 10.1053/j.gastro.2023.02.002

Editorial

Genetically Engineered Mouse Models Shine New Light on Decades-old Story of Trypsin in Pancreatitis

Bomi Lee et al. Gastroenterology. 2023 Apr.

. 2023 Apr;164(4):524-526.

doi: 10.1053/j.gastro.2023.02.002. Epub 2023 Feb 10.

Authors

Bomi Lee¹, Sohail Z Husain², Ilya Gukovsky³

Affiliations

¹ Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Stanford University, Stanford, California.
² Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Stanford University, Stanford, California. Electronic address: Sohail.husain@stanford.edu.
³ Department of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California.

PMID: 36773768
PMCID: PMC10680306
DOI: 10.1053/j.gastro.2023.02.002

No abstract available

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Conflict of interest statement

Conflicts of interest

This author discloses the following: Sohail Z. Husain is a member of the scientific advisory board for Atias. The remaining authors disclose no conflicts.

Comment on

Trypsin Activity in Secretagogue-induced Murine Pancreatitis Is Solely Elicited by Cathepsin B and Does Not Mediate Key Pathologic Responses.
Geisz A, Tran T, Orekhova A, Sahin-Tóth M. Geisz A, et al. Gastroenterology. 2023 Apr;164(4):684-687.e4. doi: 10.1053/j.gastro.2023.01.004. Epub 2023 Jan 11. Gastroenterology. 2023. PMID: 36641042 Free PMC article. No abstract available.

References

1. Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol 2019; 16:479–496. - PubMed
1. Peery AF, Crockett SD, Murphy CC, et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2021. Gastroenterology 2022; 162:621–644. - PMC - PubMed
1. Chiari H. Uber die Selbstverdaung des menshlichen Pankreas. Z Heilik 1896;17:69–96.
1. Sendler M, Lerch MM. The complex role of trypsin in pancreatitis. Gastroenterology 2020;158:822–826. - PubMed
1. Kunitz M, Northrop JH. Autocatalytic activation of trypsinogen in the presence of concentrated ammonium or magnesium sulfate. Science 1934;80:190. - PubMed

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Genetically Engineered Mouse Models Shine New Light on Decades-old Story of Trypsin in Pancreatitis

Affiliations

Genetically Engineered Mouse Models Shine New Light on Decades-old Story of Trypsin in Pancreatitis

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