Olfactory dysfunction after COVID-19: metanalysis reveals persistence in one-third of patients 6 months after initial infection

Siqi Hu¹, Shenghui Zhang¹, Yao You¹, Jiake Tang¹, Chen Chen¹, Chunyi Wang¹, Wen Wen¹, Mingwei Wang², Juan Chen³, Lin Luo⁴, Yongran Cheng⁵, Mengyun Zhou⁶, Xuezhi Zhao⁷, Tao Tan⁸, Guanming Qi⁹, Zhanhui Feng¹⁰

Affiliations

¹ Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou Institute of Cardiovascular Diseases, Hangzhou 310015, China; Hangzhou Lin'an Fourth People's Hospital, Hangzhou 311321, China.
² Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou Institute of Cardiovascular Diseases, Hangzhou 310015, China; Hangzhou Lin'an Fourth People's Hospital, Hangzhou 311321, China. Electronic address: wmw990556@hznu.edu.cn.
³ Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou Institute of Cardiovascular Diseases, Hangzhou 310015, China; Hangzhou Lin'an Fourth People's Hospital, Hangzhou 311321, China. Electronic address: chenjuan564453@163.com.
⁴ Hangzhou Ruolin Hospital Management Co. Ltd, Hangzhou, 310007, China.
⁵ School of Public Health, Hangzhou Medical College, Hangzhou, 311300, China.
⁶ Department of Molecular & Cellular Physiology, Shinshu University School of Medicine, 3900803, Japan.
⁷ Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China.
⁸ Faculty of Applied Science, Macao Polytechnic University, 999078, Macao Special Administrative Region of China.
⁹ Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, Boston, MA 02111, USA.
¹⁰ Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.

PMID: 36773893
PMCID: PMC9911154
DOI: 10.1016/j.jinf.2023.01.041

Meta-Analysis

Olfactory dysfunction after COVID-19: metanalysis reveals persistence in one-third of patients 6 months after initial infection

Siqi Hu et al. J Infect. 2023 May.

. 2023 May;86(5):516-519.

doi: 10.1016/j.jinf.2023.01.041. Epub 2023 Feb 10.

Authors

Affiliations

¹ Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou Institute of Cardiovascular Diseases, Hangzhou 310015, China; Hangzhou Lin'an Fourth People's Hospital, Hangzhou 311321, China.
² Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou Institute of Cardiovascular Diseases, Hangzhou 310015, China; Hangzhou Lin'an Fourth People's Hospital, Hangzhou 311321, China. Electronic address: wmw990556@hznu.edu.cn.
³ Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou Institute of Cardiovascular Diseases, Hangzhou 310015, China; Hangzhou Lin'an Fourth People's Hospital, Hangzhou 311321, China. Electronic address: chenjuan564453@163.com.
⁴ Hangzhou Ruolin Hospital Management Co. Ltd, Hangzhou, 310007, China.
⁵ School of Public Health, Hangzhou Medical College, Hangzhou, 311300, China.
⁶ Department of Molecular & Cellular Physiology, Shinshu University School of Medicine, 3900803, Japan.
⁷ Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China.
⁸ Faculty of Applied Science, Macao Polytechnic University, 999078, Macao Special Administrative Region of China.
⁹ Division of Pulmonary, Critical Care and Sleep, Tufts Medical Center, Boston, MA 02111, USA.
¹⁰ Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.

PMID: 36773893
PMCID: PMC9911154
DOI: 10.1016/j.jinf.2023.01.041

No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare no competing interests.

Figures

**Fig. 1**
(a) The pooled prevalence of persistent olfactory dysfunction after 6 months of infection in COVID-19 can be divided into 6 months to 1 year and more than 1 year. (b) The pooled prevalence of persistent anosmia after 6 months of infection in COVID-19. (c) The pooled prevalence of persistent hyposmia after 6 months of infection in COVID-19.

See this image and copyright information in PMC

Comment on

Persistent olfactory dysfunction 2 years after onset of COVID-19.
Deng YK, Shi KT, Liu Z, Zeng M. Deng YK, et al. J Infect. 2023 Feb;86(2):154-225. doi: 10.1016/j.jinf.2022.11.024. Epub 2022 Nov 29. J Infect. 2023. PMID: 36460170 Free PMC article. No abstract available.

References

1. Deng Y.K., Shi K.T., Liu Z., Zeng M. Persistent olfactory dysfunction 2 years after onset of COVID-19. J Infect. 2023;86(2):154–225. - PMC - PubMed
1. Alfadda A.A., Rafiullah M., Alkhowaiter M., Alotaibi N., Alzahrani M., Binkhamis K., et al. Clinical and biochemical characteristics of people experiencing post-coronavirus disease 2019-related symptoms: a prospective follow-up investigation. Front Med. 2022;9 - PMC - PubMed
1. Lechien J.R., Vaira L.A., Saussez S. Prevalence and 24-month recovery of olfactory dysfunction in COVID-19 patients: a multicentre prospective study. J. Intern Med. 2023;293(1):82–90. - PMC - PubMed
1. Yaylacı A., Azak E., Önal A., Aktürk D.R., Karadenizli A. Effects of classical olfactory training in patients with COVID-19-related persistent loss of smell. Eur Arch Otorhinolaryngol. 2022:1–7. - PMC - PubMed
1. Ballering A.V., van Zon S.K.R., Olde Hartman T.C., Rosmalen J.G.M. Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study. Lancet. 2022;400(10350):452–461. - PMC - PubMed

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Olfactory dysfunction after COVID-19: metanalysis reveals persistence in one-third of patients 6 months after initial infection

Affiliations

Olfactory dysfunction after COVID-19: metanalysis reveals persistence in one-third of patients 6 months after initial infection

Authors

Affiliations

Conflict of interest statement

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References

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Medical