Effectiveness and feasibility of three types of parent reminders to increase adolescent human papillomavirus (HPV) vaccination

Affiliations

¹ UCLA Center for Cancer Prevention and Control Research, UCLA Kaiser Permanente Center for Health Equity, Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA 90095-6900, USA. Electronic address: bglenn@ucla.edu.
² UCLA Center for Cancer Prevention and Control Research, Department of Biostatistics, UCLA Kaiser Permanente Center for Health Equity, Fielding School of Public Health, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, Los Angeles, CA 90095-6900, USA. Electronic address: ccrespi@ucla.edu.
³ UCLA Center for Cancer Prevention and Control Research, UCLA Kaiser Permanente Center for Health Equity, Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA 90095-6900, USA. Electronic address: aherrmann@ucla.edu.
⁴ UCLA Center for Cancer Prevention and Control Research, UCLA Kaiser Permanente Center for Health Equity, Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA 90095-6900, USA. Electronic address: nnonzee@coh.org.
⁵ Northeast Valley Health Corporation, San Fernando Health Center, 1600 San Fernando Rd, San Fernando, CA 91340, USA. Electronic address: debrarosen@nevhc.org.
⁶ Northeast Valley Health Corporation, San Fernando Health Center, 1600 San Fernando Rd, San Fernando, CA 91340, USA. Electronic address: christinepark@nevhc.org.
⁷ Northeast Valley Health Corporation, San Fernando Health Center, 1600 San Fernando Rd, San Fernando, CA 91340, USA. Electronic address: ginajohnson@nevhc.org.
⁸ UCLA Center for Cancer Prevention and Control Research, UCLA Kaiser Permanente Center for Health Equity, Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA 90095-6900, USA. Electronic address: clichang@ucla.edu.
⁹ Disease Control Bureau, Los Angeles County Department of Public Health, 2615 S Grand Ave #500, Los Angeles, CA 90007, USA. Electronic address: risinghal@ph.lacounty.gov.
¹⁰ Department of Health Services, University of Washington School of Public Health and Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA.. Electronic address: vtaylor@fhcrc.org.
¹¹ UCLA Center for Cancer Prevention and Control Research, UCLA Kaiser Permanente Center for Health Equity, Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA 90095-6900, USA. Electronic address: bastani@ucla.edu.

PMID: 36773962
PMCID: PMC10707435
DOI: 10.1016/j.ypmed.2023.107448

Effectiveness and feasibility of three types of parent reminders to increase adolescent human papillomavirus (HPV) vaccination

Beth A Glenn et al. Prev Med. 2023 Apr.

. 2023 Apr:169:107448.

doi: 10.1016/j.ypmed.2023.107448. Epub 2023 Feb 10.

Authors

Affiliations

¹ UCLA Center for Cancer Prevention and Control Research, UCLA Kaiser Permanente Center for Health Equity, Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA 90095-6900, USA. Electronic address: bglenn@ucla.edu.
² UCLA Center for Cancer Prevention and Control Research, Department of Biostatistics, UCLA Kaiser Permanente Center for Health Equity, Fielding School of Public Health, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, Los Angeles, CA 90095-6900, USA. Electronic address: ccrespi@ucla.edu.
³ UCLA Center for Cancer Prevention and Control Research, UCLA Kaiser Permanente Center for Health Equity, Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA 90095-6900, USA. Electronic address: aherrmann@ucla.edu.
⁴ UCLA Center for Cancer Prevention and Control Research, UCLA Kaiser Permanente Center for Health Equity, Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA 90095-6900, USA. Electronic address: nnonzee@coh.org.
⁵ Northeast Valley Health Corporation, San Fernando Health Center, 1600 San Fernando Rd, San Fernando, CA 91340, USA. Electronic address: debrarosen@nevhc.org.
⁶ Northeast Valley Health Corporation, San Fernando Health Center, 1600 San Fernando Rd, San Fernando, CA 91340, USA. Electronic address: christinepark@nevhc.org.
⁷ Northeast Valley Health Corporation, San Fernando Health Center, 1600 San Fernando Rd, San Fernando, CA 91340, USA. Electronic address: ginajohnson@nevhc.org.
⁸ UCLA Center for Cancer Prevention and Control Research, UCLA Kaiser Permanente Center for Health Equity, Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA 90095-6900, USA. Electronic address: clichang@ucla.edu.
⁹ Disease Control Bureau, Los Angeles County Department of Public Health, 2615 S Grand Ave #500, Los Angeles, CA 90007, USA. Electronic address: risinghal@ph.lacounty.gov.
¹⁰ Department of Health Services, University of Washington School of Public Health and Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA.. Electronic address: vtaylor@fhcrc.org.
¹¹ UCLA Center for Cancer Prevention and Control Research, UCLA Kaiser Permanente Center for Health Equity, Department of Health Policy and Management, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, University of California Los Angeles, 650 Charles E Young Dr. S, Los Angeles, CA 90095-6900, USA. Electronic address: bastani@ucla.edu.

PMID: 36773962
PMCID: PMC10707435
DOI: 10.1016/j.ypmed.2023.107448

Abstract

Parent reminders have produced modest improvements in human papillomavirus (HPV) vaccination among adolescents. However, little prior research has compared the effectiveness and feasibility of different HPV reminder types in resource-limited settings. We conducted a quasi-experimental study (2016-2017) to evaluate the effectiveness of three parent reminder types (mailed letters, robocalls, text messages) on next-dose HPV vaccine receipt among 12-year-olds in a large Federally Qualified Health Center in Los Angeles County. Six clinics were matched into three pairs: randomly assigning one clinic within each pair to intervention and control. Intervention clinics were randomly assigned to deliver one of the three parent reminder types. We calculated rates of next-dose vaccine receipt and assessed intervention effects using logistic regression models. We calculated the proportion of each type of reminder successfully delivered as a feasibility measure. The study sample comprised 877 12-year-olds due for an HPV vaccine dose (47% female, >85% Latino). At 4-month follow-up, 23% of intervention patients received an HPV vaccine dose compared to only 12% of control patients. Overall, receipt of any reminder increased rates of the next-needed HPV vaccine compared to usual care (p = 0.046). Significant improvements were observed for text reminders (p = 0.036) and boys (p = 0.006). Robocalls were the least feasible reminder type. Text message reminders are feasible and effective for promoting HPV vaccination. Future research is needed to assess the effectiveness and feasibility of reminders compared to other vaccine promotion strategies.

Keywords: Cervical cancer; Disparities; Human papillomavirus; Implementation science; Text message reminders; Uninsured; Vaccination.

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Conflict of interest statement

Declaration of Competing Interest No authors have reported any conflicts of interest relevant to the project.

Figures

**Fig. 1.**
Study Design. Six clinics were paired on baseline HPV vaccination rates, adolescent patient population size, and clinic location, and clinics within each pair were randomly assigned to usual care or an HPV vaccine reminder intervention. For each reminder type, rates of HPV vaccine next-dose (dose 1 or 2) receipt for 12-year-olds were compared between intervention and control clinics at 4-month follow-up.

**Fig. 2.**
Percent of reminders successfully delivered out of attempted by reminder type.

See this image and copyright information in PMC

References

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Effectiveness and feasibility of three types of parent reminders to increase adolescent human papillomavirus (HPV) vaccination

Affiliations

Effectiveness and feasibility of three types of parent reminders to increase adolescent human papillomavirus (HPV) vaccination

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources