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Multicenter Study
. 2023 Feb 11;23(1):83.
doi: 10.1186/s12872-022-03017-6.

One-year outcomes of catheter ablation for atrial fibrillation in young patients

Andrew S Tseng  1 , Harsh P Patel  2 , Ashish Kumar  3 , Chinmay Jani  4 , Kirtenkumar Patel  5 , Rahul Jaswaney  6 , Samarthkumar Thakkar  7 , Narayan G Kowlgi  1 , Sourbha S Dani  8 , Shilpkumar Arora  9 , Siva K Mulpuru  1 , Malini Madhavan  1 , Ammar M Killu  1 , Yong-Mei Cha  1 , Christopher V DeSimone  1 , Abhishek Deshmukh  10   11
Affiliations
Multicenter Study

One-year outcomes of catheter ablation for atrial fibrillation in young patients

Andrew S Tseng et al. BMC Cardiovasc Disord. .

Abstract

Background: Atrial fibrillation (AF) is relatively less frequent in younger patients (age < 50). Recently, studies have suggested that early restoration of sinus rhythm may lead to improved outcomes compared with rate control, however the efficacy of catheter ablation for AF in young is scarce.

Methods: We included all hospitalized patients between 18 and 50 years with a diagnosis of AF from the Nationwide Readmission Database 2016-2017 from the Healthcare Cost and Utilization Project. Demographic and comorbidity data were collected and analyzed. Outcomes assessed included one-year AF readmission rates, all-cause readmission, ischemic stroke, and all-cause mortality. Subgroup analyses were performed for all demographic and comorbidity variables.

Results: Overall, 52,598 patients (medium age 44, interquartile range 38-48, female 25.7%) were included in the study, including 2,146 (4.0%) who underwent catheter ablation for AF. Patients who underwent catheter ablation had a significantly lower rate of readmission for AF or any cause at one year (adjusted hazard ratios (HR) of 0.52 [95% confidence interval (CI): 0.43-0.63] and HR of 0.81 [95% CI: 0.72-0.89], respectively). There was no difference in 1-year readmission for stroke or all-cause mortality between the two groups. Subgroup analyses showed a consistent reduction in the risk of AF readmission among major demographic and comorbidity subgroups.

Conclusion: Catheter ablation in young patients with AF was associated with a reduction in 1-year AF related and all-cause readmissions. These data merit further prospective investigation for validation, through dedicated registries and multicenter collaborations to include young AF from diverse population.

Keywords: Atrial fibrillation; Catheter ablation; Ischemic stroke; Readmission; Young.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of cohort derivation. Flow diagram showing cohort derivation based on inclusion and exclusion criteria
Fig. 2
Fig. 2
Kaplan–Meier curves of outcomes of interest by ablation status. The Kaplain-Meier curves for freedom from all-cause mortality, stroke readmission, AF readmission, and any readmission is shown, where the blue curve represents patients without ablation and red curve represents patients with ablation. The number at risk at each major time point is provided. The adjusted hazard ratios are provided
See this image and copyright information in PMC

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