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. 2023;83(1):82-95.

[Invasive aspergillosis: definitions, diagnosis, and treatment]

[Article in Spanish]
Yesica Lamberto  1 , Cecilia Domínguez  1 , Alicia Arechavala  2 , Pablo Saúl  1 , Viviana Chediack  1 , Eleonora Cunto  3
Affiliations
  • PMID: 36774601
Free article

[Invasive aspergillosis: definitions, diagnosis, and treatment]

[Article in Spanish]
Yesica Lamberto et al. Medicina (B Aires). 2023.
Free article

Abstract
in English, Spanish

Invasive aspergillosis (IA) is a serious disease with high mortality. There are several risk factors and in-hospital outbreaks related with construction have been described. An entity related to COVID-19 infection, known as COVID-19 associated pulmonary aspergillosis (CAPA), has recently appeared. Early and appropriate treatment is of paramount importance, especially in immunocompromised and critically ill patients. Diagnosis is based on recognition of predisposing factors, clinical signs, imaging, direct examination, culture, histopathology, and biomarkers such as galactomannan. The drug of choice is voriconazole, but alternative therapies must be taken into account given the increasing presence of resistant isolates.

La aspergilosis invasiva (AI) es una enfermedad grave y con alta mortalidad. Existen factores de riesgo y se describen brotes intrahospitalarios relacionados con construcciones. También se describe una entidad relacionada con la infección por COVID-19, conocida como aspergilosis pulmonar asociada a COVID-19 (APAC). Es de vital importancia implementar un tratamiento adecuado y precoz, especialmente en pacientes inmunocomprometidos y críticamente enfermos. El diagnóstico se basa en reconocer los factores predisponentes, la clínica, la obtención de imágenes, exámenes directos, cultivos, histopatología y biomarcadores como el galactomanano. La droga de elección es el voriconazol, pero se deben conocer las alternativas terapéuticas dada la creciente presencia de aislamientos resistentes.

Keywords: antifungals; aspergillosis; galactomannan; invasive mycosis; voriconazole.

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