Adjuvant ipilimumab and nivolumab in renal cell carcinoma: more questions than answers
- PMID: 36774931
- DOI: 10.1016/S0140-6736(22)02631-9
Adjuvant ipilimumab and nivolumab in renal cell carcinoma: more questions than answers
Conflict of interest statement
UMV reports grants from Fond'Action; consulting fees (for advisory boards and symposia) from Dr Grasso Consulting, Kantonsspital Aaurau, Chur, Inselspital Bern, and SAMO (personal); consulting fees (for advisory boards and symposia) from Bayer, Astellas, Janssen-Cilag, Merck, Pfizer, MSD, BMS, Ipsen, and Novartis AAA (institutional); expert testimonials for Merck and BMS (institutional); and travel grants from Merck, Janssen-Cilag, and Ipsen. DM reports research grants from BMS, Exelixis, Merck, Genentech, Roche, Pfizer, X4 Pharma, Alkermes, and Eisai; and consulting fees (for advisory boards and membership of steering committees) from Roche, BMS, Exelixis, Merck EMD Serono, Eli Lilly and Company, Iovance, Calithera Biosciences, Johnson & Johnson, Aveo, Clinigen, MSD, Pfizer, Synthekine, Eisai, Alkermes, and Werewolf Therapuetics. TP reports grants from AstraZeneca, Roche, BMS, Exelixis, Ipsen, Merck, MSD, Novartis, Pfizer, Seattle Genetics, Merck Serono, Astellas, Johnson & Johnson, and Eisai; consulting fees (for advisory boards, symposia, and membership of steering committees) from AstraZeneca, Roche, BMS, Exelixis, Incyte, Ipsen, Merck, MSD, Novartis, Pfizer, Seattle Genetics, Merck Serono, Astellas, Johnson & Johnson, Eisai, and Mashup; and travel fees for attending meetings from Roche, Pfizer, MSD, AstraZeneca, and Ipsen. BMS, Roche, MSD, and Merck Serono all manufacture immune checkpoint inhibitors (ipilimumab, nivolumab, pembrolizumab, avelumab, and atezolizumab), which are discussed in this Comment, and the other listed companies above are unrelated to this topic but related to cancer research.
Comment on
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Adjuvant nivolumab plus ipilimumab versus placebo for localised renal cell carcinoma after nephrectomy (CheckMate 914): a double-blind, randomised, phase 3 trial.Lancet. 2023 Mar 11;401(10379):821-832. doi: 10.1016/S0140-6736(22)02574-0. Epub 2023 Feb 9. Lancet. 2023. PMID: 36774933 Free PMC article. Clinical Trial.
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