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Review
. 2023 Mar 31;58(1):2-12.
doi: 10.5045/br.2023.2022192. Epub 2023 Feb 8.

Effects of immune system cells in GvHD and corresponding therapeutic strategies

Maryam Jadid Tavaf  1 , Mahboobeh Ebrahimi Verkiani  1 , Fateme Poorhoseini Hanzaii  1 , Mina Soufi Zomorrod  1
Affiliations
Review

Effects of immune system cells in GvHD and corresponding therapeutic strategies

Maryam Jadid Tavaf et al. Blood Res. .

Abstract

Allogeneic tissue transplantation is one of the most effective treatments for several diseases and injuries, in particular, malignant and non-malignant hematological conditions. Following this procedure, transplanted tissue encounters various complications, one of the most serious being graft-versus-host disease (GvHD). The management of GvHD directly affects the success of transplantation and the survival rate of the patient; therefore, many studies have focused on GvHD prevention and control. This review briefly explains the transplantation process, causes of graft rejection, and importance of the human leukocyte antigen system. Initially, we address the pathophysiology and immunobiology of GvHD, the cells involved in this complication, the differences between chronic and acute GvHD, and the importance of graft-versus-leukemia. Interestingly, various types of immune cells are involved in GvHD pathogenesis. After explaining how these cells affect the GvHD process, we discuss the studies conducted to control and reduce GvHD symptoms.

Keywords: Graft rejection; GvHD; HLA system.

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Conflict of interest statement

Authors’ Disclosures of Potential Conflicts of Interest

No potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1
The role of natural killer cells in graft-versus-host disease (GvHD).
Fig. 2
Fig. 2
Dendritic cell (DC) subsets and their corresponding functions.
Fig. 3
Fig. 3
Mesenchymal stem cell (MSC) effects on immune cell types.
Fig. 4
Fig. 4
Drug targets for treating acute graft-versus-host disease (aGvHD).
See this image and copyright information in PMC

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