Asia-pacific consensus on osteoporotic fracture prevention in postmenopausal women with low bone mass or osteoporosis but no fragility fractures

Chun-Feng Huang¹, Jung-Fu Chen², Ian R Reid³, Wing P Chan⁴, Peter Robert Ebeling⁵, Bente Langdahl⁶, Shih-Te Tu⁷, Toshio Matsumoto⁸, Ding-Cheng Chan⁹, Yoon-Sok Chung¹⁰, Fang-Ping Chen¹¹, E Michael Lewiecki¹², Keh-Sung Tsai¹³, Rong-Sen Yang¹⁴, Seng Bin Ang¹⁵, Ko-En Huang¹⁶, Yin-Fan Chang¹⁷, Chung-Hwan Chen¹⁸, Joon-Kiong Lee¹⁹, Hsin-I Ma²⁰, Weibo Xia²¹, Ambrish Mithal²², David L Kendler²³, Cyrus Cooper²⁴, Jawl-Shan Hwang²⁵, Chih-Hsing Wu²⁶

Affiliations

¹ Division of Family Medicine, En Chu Kong Hospital, New Taipei City, Taiwan; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Leisure Services Management, Chaoyang University of Technology, Taichung, Taiwan.
² Division of Metabolism and Endocrinology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
³ Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
⁴ Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
⁵ Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
⁶ Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
⁷ Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
⁸ Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima, Japan.
⁹ Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
¹⁰ Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.
¹¹ Keelung Osteoporosis Prevention and Treatment Center, Chang Gung Memorial Hospital, Keelung, Taiwan.
¹² New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, USA.
¹³ Superintendent Office, Far Eastern Polyclinic of Far Eastern Medical Foundation, Taipei, Taiwan.
¹⁴ Department of Orthopaedics, National Taiwan University Hospital, Taipei, Taiwan.
¹⁵ Menopause Unit and Family Medicine Service, KK Women's and Children's Hospital, Singapore, Singapore.
¹⁶ Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
¹⁷ Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
¹⁸ Orthopaedic Research Center and Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Regeneration Medicine and Cell Therapy Research Center and Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital and Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
¹⁹ Beacon Hospital, Petaling Jaya, Selangor, Malaysia.
²⁰ Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
²¹ Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
²² Division of Endocrinology and Diabetes, Medanta the Medicity, Gurgaon, Haryana, India.
²³ Department of Medicine (Endocrinology), University of British Columbia, Vancouver, British Columbia, Canada.
²⁴ Oxford National Institute for Health Biomedical Research Centre, University of Oxford, Windmill Road, Oxford, United Kingdom.
²⁵ Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
²⁶ Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: paulo@mail.ncku.edu.tw.

PMID: 36775679
DOI: 10.1016/j.jfma.2023.01.013

Free article

Asia-pacific consensus on osteoporotic fracture prevention in postmenopausal women with low bone mass or osteoporosis but no fragility fractures

Chun-Feng Huang et al. J Formos Med Assoc. 2023.

Free article

. 2023:122 Suppl 1:S14-S20.

doi: 10.1016/j.jfma.2023.01.013. Epub 2023 Feb 10.

Authors

Affiliations

¹ Division of Family Medicine, En Chu Kong Hospital, New Taipei City, Taiwan; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Leisure Services Management, Chaoyang University of Technology, Taichung, Taiwan.
² Division of Metabolism and Endocrinology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
³ Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
⁴ Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
⁵ Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
⁶ Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
⁷ Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
⁸ Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima, Japan.
⁹ Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
¹⁰ Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.
¹¹ Keelung Osteoporosis Prevention and Treatment Center, Chang Gung Memorial Hospital, Keelung, Taiwan.
¹² New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, USA.
¹³ Superintendent Office, Far Eastern Polyclinic of Far Eastern Medical Foundation, Taipei, Taiwan.
¹⁴ Department of Orthopaedics, National Taiwan University Hospital, Taipei, Taiwan.
¹⁵ Menopause Unit and Family Medicine Service, KK Women's and Children's Hospital, Singapore, Singapore.
¹⁶ Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
¹⁷ Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
¹⁸ Orthopaedic Research Center and Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Regeneration Medicine and Cell Therapy Research Center and Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital and Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
¹⁹ Beacon Hospital, Petaling Jaya, Selangor, Malaysia.
²⁰ Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
²¹ Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
²² Division of Endocrinology and Diabetes, Medanta the Medicity, Gurgaon, Haryana, India.
²³ Department of Medicine (Endocrinology), University of British Columbia, Vancouver, British Columbia, Canada.
²⁴ Oxford National Institute for Health Biomedical Research Centre, University of Oxford, Windmill Road, Oxford, United Kingdom.
²⁵ Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
²⁶ Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: paulo@mail.ncku.edu.tw.

PMID: 36775679
DOI: 10.1016/j.jfma.2023.01.013

Abstract

Postmenopausal women are at significant risk for osteoporotic fractures due to their rapid bone loss. Half of all postmenopausal women will get an osteoporosis-related fracture over their lifetime, with 25% developing a spine deformity and 15% developing a hip fracture. By 2050, more than half of all osteoporotic fractures will occur in Asia, with postmenopausal women being the most susceptible. Early management can halt or even reverse the progression of osteoporosis. Consequently, on October 31, 2020, the Taiwanese Osteoporosis Association hosted the Asia-Pacific (AP) Postmenopausal Osteoporotic Fracture Prevention (POFP) consensus meeting, which was supported by the Asian Federation of Osteoporosis Societies (AFOS) and the Asia Pacific Osteoporosis Foundation (APOF). International and domestic experts developed ten applicable statements for the prevention of osteoporotic fractures in postmenopausal women with low bone mass or osteoporosis but no fragility fractures in the AP region. The experts advocated, for example, that postmenopausal women with a high fracture risk be reimbursed for pharmaceutical therapy to prevent osteoporotic fractures. More clinical experience and data are required to modify intervention tactics.

Keywords: Asia–pacific; Consensus; Osteoporosis; Osteoporotic fracture; Postmenopausal women; Prevention.

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Conflict of interest statement

Declaration of competing interest Chih-Hsing Wu received honoraria for lectures, attending meetings, and/or travel from Eli Lilly, Roche, Amgen, Merck, Servier laboratories, GE Lunar, Harvester, TCM Biotech, and Alvogen/Lotus. E Michael Lewiecki is an investigator, consultant, and speaker for Amgen, and an investigator for Radius.

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Asia-pacific consensus on osteoporotic fracture prevention in postmenopausal women with low bone mass or osteoporosis but no fragility fractures

Affiliations

Asia-pacific consensus on osteoporotic fracture prevention in postmenopausal women with low bone mass or osteoporosis but no fragility fractures

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous