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. 2022 Sep 24;10(3):219-226.
doi: 10.2478/jtim-2022-0039. eCollection 2022 Sep.

Crosstalk Between Adipose Tissue and the Heart: An Update

Chao Li  1 , Xue-Nan Sun  1 , Shangang Zhao  1 , Philipp E Scherer  1   2
Affiliations

Crosstalk Between Adipose Tissue and the Heart: An Update

Chao Li et al. J Transl Int Med. .

Abstract

It is important to understand how different human organs coordinate and interact with each other. Since obesity and cardiac disease frequently coincide, the crosstalk between adipose tissues and heart has drawn attention. We appreciate that specific peptides/proteins, lipids, nucleic acids, and even organelles shuttle between the adipose tissues and heart. These bioactive components can profoundly affect the metabolism of cells in distal organs, including heart. Importantly, this process can be dysregulated under pathophysiological conditions. This also opens the door to efforts targeting these mediators as potential therapeutic strategies to treat patients who manifest diabetes and cardiovascular disease. Here, we summarize the recent progress toward a better understanding of how the adipose tissues and heart interact with each other.

Keywords: adipose tissue; cardiovascular disease; crosstalk; heart; obesity.

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Conflict of interest statement

Conflict of Interest None declared.

Figures

Figure 1
Figure 1
The crosstalk between adipose tissue and the heart.
See this image and copyright information in PMC

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