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. 2023 Feb 5:16:359-367.
doi: 10.2147/CCID.S398134. eCollection 2023.

Association of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio with Gastrointestinal Involvement of Immunoglobulin a Vasculitis

Xinyi Shao #  1 , Hao Li #  2 , Tingqiao Chen  1 , Yangmei Chen  1 , Xue Qin  1 , Lin Liu  1 , Xiaoyan Luo  2 , Jin Chen  1
Affiliations

Association of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio with Gastrointestinal Involvement of Immunoglobulin a Vasculitis

Xinyi Shao et al. Clin Cosmet Investig Dermatol. .

Abstract

Objective: To illustrate the association of monocyte to high-density lipoprotein cholesterol ratio (MHR) and other serum indicators with the pathogenesis and prognosis of immunoglobulin A vasculitis (IgAV) patients in different subgroups.

Methods: A total of 158 adult patients and 113 healthy controls were enrolled, and the clinical presentation and laboratory indexes were comprehensively assessed.

Results: IgAV patients show significantly elevated levels of inflammatory parameters and lipid profiles compared to healthy controls (P < 0.05). Higher levels of the MHR and other normal inflammatory indicators were found in patients with Gastrointestinal (GI) involvement compared to other subgroups. And in group with GI involvement, significantly higher white blood cell (WBC), neutrophil, complement 4 (C4), NLR (neutrophil-to-lymphocyte ratio) and PLR (platelet-to-lymphocyte ratio) levels and lower levels of apolipoprotein-a (Apo-a) were observed. Their correlation analysis demonstrated positive results between MHR level and white blood cell (WBC) count (r = 0.416, P = 0.034), D-Dimer (r = 0.464, P = 0.026) and monocyte (r = 0.947, P < 0.001). And the time until first remission of skin purpura was shown positively correlated with their age (r = 0.456, P = 0.043), C-reactive protein (CRP) level (r = 0.641, P = 0.018), D-Dimer level (r = 0.502, P = 0.040) while negatively correlated with albumin (Alb) level (r=-0.626, P = 0.003) and low-density lipoprotein (LDL) level (r=-0.478, P = 0.033).

Conclusion: Our study suggests that those biomarkers represented for inflammatory responses, lipid profile and immunological functions have significant differences in the subgroups of adult IgAV patients. In addition, we also found that MHR level may serve as a potential biomarker for the pathogenesis and prognosis of IgAV patients with GI involvement.

Keywords: endothelial dysfunction; gastrointestinal involvement; immunoglobulin A vasculitis; inflammation; monocyte-to-high-density lipoprotein cholesterol ratio.

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Conflict of interest statement

All authors declare no potential conflicts of interest, including any relevant financial interests, activities, relationships, or affiliations for this work.

Figures

Figure 1
Figure 1
Diagnoses of Immunoglobulin A vasculitis. Skin:Only skin palpable epilepsy was present and evidence of other system involvement was excluded. Gastrointestinal Involvement: Skin palpable epilepsy with digestive system symptoms abdominal pain, stool occult blood positive, intussusception, intestinal obstruction, intestinal perforation, etc.).Joint involvement: Skin palpable epilepsy with swelling, pain / tenderness or arthritis in and around joints, with limited movement.Kidney involvement:Skin palpable epilepsy with kidney injury (hematuria, proteinuria, tubular urine, hypertension, etc.).Multiple system involvement:Except for simplex type, two or more of the other three types exist at the same time.
See this image and copyright information in PMC

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