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Review
. 2023 Jan 26:13:1114450.
doi: 10.3389/fonc.2023.1114450. eCollection 2023.

Advances in the intraoperative delineation of malignant glioma margin

Shan Jiang  1 , Huihui Chai  1 , Qisheng Tang  1
Affiliations
Review

Advances in the intraoperative delineation of malignant glioma margin

Shan Jiang et al. Front Oncol. .

Abstract

Surgery plays a critical role in the treatment of malignant glioma. However, due to the infiltrative growth and brain shift, it is difficult for neurosurgeons to distinguish malignant glioma margins with the naked eye and with preoperative examinations. Therefore, several technologies were developed to determine precise tumor margins intraoperatively. Here, we introduced four intraoperative technologies to delineate malignant glioma margin, namely, magnetic resonance imaging, fluorescence-guided surgery, Raman histology, and mass spectrometry. By tracing their detecting principles and developments, we reviewed their advantages and disadvantages respectively and imagined future trends.

Keywords: FGS; MRI; Raman histology; glioma; intraoperative; mass spectrometry.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Graphical abstract showing the four intraoperative technologies for precise depictions of malignant glioma margin.
See this image and copyright information in PMC

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