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. 2023 Jan 26:36:10979.
doi: 10.3389/ti.2023.10979. eCollection 2023.

Cytokine and Chemokine Secretome and Risk of CMV Infection Following Discontinuation of Valganciclovir Prophylaxis

Mario Fernández-Ruiz  1   2   3 , Patricia Parra  1   2 , Tamara Ruiz-Merlo  1   2 , Natalia Redondo  1   2 , Isabel Rodríguez-Goncer  1   2 , Amado Andrés  3   4 , José María Aguado  1   2   3
Affiliations

Cytokine and Chemokine Secretome and Risk of CMV Infection Following Discontinuation of Valganciclovir Prophylaxis

Mario Fernández-Ruiz et al. Transpl Int. .
No abstract available

Keywords: IP-10; chemokine; cytokine; cytomegalovirus; kidney transplantation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
(A) Heatmap of the correlation between analyzed cytokines and chemokines. Values obtained in unstimulated plasma samples were subtracted from CMV peptide-stimulated samples (“CMV tube” minus “nil tube”). (B) Clinically significant (DNAemia >1,000 IU/mL) CMV infection-free survival after the discontinuation of valganciclovir prophylaxis according to expression (upregulation or downregulation) of IP-10 and (C) SDF-1α upon whole blood stimulation with CMV-specific viral peptides (log-rank p-values = 0.001 and 0.027, respectively). Three patients were censored at days 92, 159 and 339 because of graft loss (rejection), loss to follow-up and death (gastric adenocarcinoma), respectively. The criteria for classifying a given recipient in the upregulated or regulated categories was that the increment (Δ) in plasma IP-10 or SDF-1α levels from unstimulated baseline samples to CMV peptide-stimulated samples (“CMV tube” minus “nil tube”) was positive (Δ >0) or zero or negative (Δ ≤0), respectively. * p-value < 0.00007 (Bonferroni-corrected threshold for statistical significance). CMV, cytomegalovirus; GRO α, growth-related onconge α; IFN, interferon; IL, interleukin; IP-10, interferon-γ-inducible protein 10; MCP, monocyte chemoattractant protein; MIP-1, macrophage inflammatory protein 1; RANTES, regulated upon activation, normal T-cell expressed and presumably secreted; SDF-1α, stromal cell-derived factor 1α; TNF, tumor necrosis factor-α; VGCV, valganciclovir.
See this image and copyright information in PMC

References

    1. Fernández-Ruiz M, Rodríguez-Goncer I, Parra P, Ruiz-Merlo T, Corbella L, López-Medrano F, et al. Monitoring of CMV-specific Cell-Mediated Immunity with a Commercial ELISA-Based Interferon-γ Release Assay in Kidney Transplant Recipients Treated with Antithymocyte Globulin. Am J Transpl (2020) 20:2070–80. 10.1111/ajt.15793 - DOI - PubMed
    1. Lisboa LF, Egli A, Fairbanks J, O'Shea D, Manuel O, Husain S, et al. CCL8 and the Immune Control of Cytomegalovirus in Organ Transplant Recipients. Am J Transpl (2015) 15:1882–92. 10.1111/ajt.13207 - DOI - PubMed
    1. Dinarello CA, Novick D, Puren AJ, Fantuzzi G, Shapiro L, Mühl H, et al. Overview of Interleukin-18: More Than an Interferon-Gamma Inducing Factor. J Leukoc Biol (1998) 63:658–64. 10.1002/jlb.63.6.658 - DOI - PubMed
    1. Liu M, Guo S, Hibbert JM, Jain V, Singh N, Wilson NO, et al. CXCL10/IP-10 in Infectious Diseases Pathogenesis and Potential Therapeutic Implications. Cytokine Growth Factor Rev (2011) 22:121–30. 10.1016/j.cytogfr.2011.06.001 - DOI - PMC - PubMed
    1. Ruhwald M, Bodmer T, Maier C, Jepsen M, Haaland MB, Eugen-Olsen J, et al. Evaluating the Potential of IP-10 and MCP-2 as Biomarkers for the Diagnosis of Tuberculosis. Eur Respir J (2008) 32:1607–15. 10.1183/09031936.00055508 - DOI - PubMed