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Review
. 2023 Jan 26:14:1103141.
doi: 10.3389/fphys.2023.1103141. eCollection 2023.

Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature

Dongge Liu  1 , Shuqi Yan  1 , Pingwei Wang  1 , Qianqian Chen  1 , Yanping Liu  1 , Jiajing Cui  1 , Yujun Liang  1 , Shuping Ren  1 , Ying Gao  2
Affiliations
Review

Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature

Dongge Liu et al. Front Physiol. .

Abstract

Perfluorooctanoic acid is an artificial and non-degradable chemical. It is widely used due to its stable nature. It can enter the human body through food, drinking water, inhalation of household dust and contact with products containing perfluorooctanoic acid. It accumulates in the human body, causing potential harmful effects on human health. Based on the biodegradability and bioaccumulation of perfluorooctanoic acid in the human body, there are increasing concerns about the adverse effects of perfluorooctanoic acid exposure on kidneys. Research shows that kidney is the main accumulation organ of Perfluorooctanoic acid, and Perfluorooctanoic acid can cause nephrotoxicity and produce adverse effects on kidney function, but the exact mechanism is still unknown. In this review, we summarize the relationship between Perfluorooctanoic acid exposure and kidney health, evaluate risks more clearly, and provide a theoretical basis for subsequent research.

Keywords: CKD; EGFR; PFAS; kidney; perfluorooctanoic acid; pfoa; renal tumors.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Overview of PFOA exposure pathways for different human populations outside of occupational settings.
FIGURE 2
FIGURE 2
Difference of renal elimination in half life of perfluorooctanoic acid.
FIGURE 3
FIGURE 3
Effects of perfluorooctanoic acid on the kidneys and mediated mechanisms.
See this image and copyright information in PMC

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