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. 2023;28(1):102-107.
doi: 10.5863/1551-6776-28.1.102. Epub 2023 Feb 3.

Inpatient Transition From Intravenous to Inhaled Treprostinil in a Pediatric Patient

David Procaccini  1 , Dennis Delany  2 , Abigail Self  2 , Patricia Lawrence Kane  3 , John D Coulson  3
Affiliations

Inpatient Transition From Intravenous to Inhaled Treprostinil in a Pediatric Patient

David Procaccini et al. J Pediatr Pharmacol Ther. 2023.

Abstract

We report a case of a 7-year old male with idiopathic pulmonary arterial hypertension, successfully transitioned from an intravenous infusion to inhaled treprostinil during inpatient admission, after his intentional removal of multiple central venous catheters. He had no clinical, echocardiographic, or serum biomarker evidence of loss of control of pulmonary arterial hypertension during the 4-day transition. The patient was discharged home without complications, and 3 weeks after discharge the patient's pulmonary hypertension remained well controlled per clinical and echocardiographic evidence, including a significantly improved 6-minute walk distance test.

Keywords: case report; prostacyclin; pulmonary arterial hypertension; transition; treprostinil.

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Conflict of interest statement

Disclosures. The authors have no competing interests to disclose. The authors had full access to all patient information in this report and take responsibility for the integrity and accuracy of the report.

References

    1. Abman SH, Hansmann G, Archer SL, et al. American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; and the American Thoracic Society Pediatric pulmonary hypertension: guidelines from the American Heart Association and American Thoracic Society. Circulation . 201524;132(21):2037–2099. - PubMed
    1. McLaughlin VV, Archer SL, Badesch DB et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J Am Coll Cardiol . 2009;53:1573–1619. - PubMed
    1. Laliberte K, Arneson C, Jeffs R et al. Pharmacokinetics and steady-state bioequivalence of treprostinil sodium (Remodulin) administered by the intravenous and subcutaneous route tonormal volunteers. J Cardiovasc Pharmacol . 2004;44(2):209–214. - PubMed
    1. Research Triangle Park, NC: United Therapeutics Corp; Feb, 2011. Remodulin (treprostinil) [package insert]
    1. Hall K, Ogawa M, Sakarovitch C et al. Subcutaneous and intravenous treprostinil pharmacokinetics in children with pulmonary vascular disease. J Cardiovasc Pharmacol . 2019;73(6):383–393. - PubMed

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