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. 2022 Jun 8;2(6):100141.
doi: 10.1016/j.xgen.2022.100141.

Global priorities for large-scale biomarker-based prospective cohorts

Rory Collins  1 , Mary K Balaconis  2 , Søren Brunak  3 , Zhengming Chen  4 , Mary De Silva  5 , J Michael Gaziano  6 , Geoffrey S Ginsburg  7 , Prabhat Jha  8 , Pablo Kuri  9 , Andres Metspalu  10 , Nicola Mulder  11 , Neil Risch  12
Affiliations

Global priorities for large-scale biomarker-based prospective cohorts

Rory Collins et al. Cell Genom. .

Abstract

The focus of this paper is on strategic approaches for establishing population-based prospective cohorts that collect and store biological samples from very large numbers of participants to help identify the determinants of common health outcomes. In particular, it aims to address key issues related to investigation of genetic, as well as social, environmental, and ancestral, diversity; generation of detailed genetic and other types of assay data; collection of detailed lifestyle and environmental exposure information; follow-up and characterization of incident health outcomes; and overcoming obstacles to data sharing and access (including capacity building). It concludes that there is a need for strategic planning at an international level (rather than the current ad hoc approach) toward the development of a carefully selected set of deeply characterized large-scale prospective cohorts that are readily accessible by researchers around the world.

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Conflict of interest statement

R.C. is the principal investigator (PI) and CEO of UK Biobank; Z.C. is the co-PI of the China Kadoorie Biobank; M.G. is the PI of the Million Veteran Program; G.G. is the chief medical and scientific officer of the All of Us Program; P.K.. is the director of Proyecto OriGen; A.M. is the head of the Estonian Biobank; and N.M. is on the advisory board of Cell Genomics.

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