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Review
. 2023 Jun;68(3):337-353.
doi: 10.1007/s12223-022-01030-y. Epub 2023 Feb 13.

Anti-inflammatory and wound healing properties of lactic acid bacteria and its peptides

Parikhshith Saravanan  1 , Pooja R  1 , Nanditaa Balachander  1 , Kesav Ram Singh K  1 , Silpa S  1 , Rupachandra S  2
Affiliations
Review

Anti-inflammatory and wound healing properties of lactic acid bacteria and its peptides

Parikhshith Saravanan et al. Folia Microbiol (Praha). 2023 Jun.

Erratum in

Abstract

Recent studies manifest an increase of inflammatory diseases at an alarming rate due to gut microbiota dysbiosis, genetic and other environmental factors. Lactic acid bacteria (LAB) are known for their antimicrobial properties and their extensive applications in food and pharmaceutical industries. Cyclic peptides are receiving increased attention due to their remarkable stability to withstand variations in temperature and pH. LAB produces anti-inflammatory that can inhibit lipopolysaccharide-induced production of proinflammatory cytokines in macrophages. The structural backbones of cyclic peptides offer a promising approach for the treatment of chronic inflammatory conditions. The current review aims to present the overview of anti-inflammatory and wound healing properties of LAB-derived cyclic peptides.

Keywords: Anti-inflammatory; Cyclic peptides; Lactic acid bacteria; Nano-drug delivery system; Wound healing.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic representation of anti-inflammatory activity of cyclic peptides at the site of inflammation. Abbreviations used: TNFα, tumor necrosis factor α; DAMP, damage-associated molecular pattern; IL 1, 6, 12, interleukin 1, 6, 12; COX 2, cyclooxygenase 2; LOX 2, lipoxygenase 2; iNOS, inducible nitric oxide synthase
See this image and copyright information in PMC

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