Synergistic effect of lecithin and alginate, CMC, or PVP in stabilizing curcumin and its potential mechanism

Abstract

This work aims to advance the understanding of the synergistic mechanism of lecithin and polymers (alginate, CMC, and PVP) in stabilizing curcumin, with a major focus on understanding the nanocomplex formation process and the main binding energy between molecules. It is demonstrated that lecithin and polymers have a synergistic effect in increasing the thermal acid, light, and digestion stability of curcumin. The potential mechanism is that the hydrophobic parts of curcumin molecules are first anchored at the region of the hydrophobic cavity of lecithin by van der Waals, while the hydrophilic parts are outward and are further encapsulated by hydrophilic polymers by van der Waals and electrostatic interaction to form a protective shell. This study contributes to our understanding of the synergistic mechanism of lecithin, polymers, and hydrophobic compounds, which can promote the synergistic use of lecithin and polymers to prepare nanocomplexes as an important tool for delivering bioactive compounds.

Keywords: Alginate (PubChem CID: 5102882); Binding energy; Bioactive compound; Carboxymethyl cellulose (PubChem CID: 24748); Curcumin (PubChem CID: 969526); Lecithin (PubChem CID: 6021688); Molecular dynamic simulation; Nanocomplex; Polyvinylpyrrolidone K16-18 (PubChem CID: 6917); Stability mechanism.