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Multicenter Study
. 2023 Apr;25(4):562-572.
doi: 10.1002/ejhf.2796. Epub 2023 Feb 26.

Use of mechanical circulatory support in patients with non-ischaemic cardiogenic shock

Benedikt Schrage  1   2 , Jonas Sundermeyer  1   2 , Benedikt Norbert Beer  1   2 , Letizia Bertoldi  3 , Alexander Bernhardt  2   4 , Stefan Blankenberg  1   2 , Jeroen Dauw  5   6 , Zouhir Dindane  7 , Dennis Eckner  8 , Ingo Eitel  2   9 , Tobias Graf  2   9 , Patrick Horn  10 , Paulus Kirchhof  1   2 , Stefan Kluge  11 , Axel Linke  7 , Ulf Landmesser  12 , Peter Luedike  13 , Enzo Lüsebrink  14 , Norman Mangner  7 , Octavian Maniuc  15 , Sven Möbius Winkler  16 , Peter Nordbeck  15 , Martin Orban  14 , Federico Pappalardo  17 , Matthias Pauschinger  8 , Michal Pazdernik  18 , Alastair Proudfoot  19 , Matthew Kelham  19 , Tienush Rassaf  13 , Hermann Reichenspurner  2   4 , Clemens Scherer  14 , Paul Christian Schulze  16 , Robert H G Schwinger  20 , Carsten Skurk  12 , Marek Sramko  18 , Guido Tavazzi  21   22 , Holger Thiele  23 , Luca Villanova  24 , Nuccia Morici  25 , Antonia Wechsler  20 , Ralf Westenfeld  10 , Ephraim Winzer  7 , Dirk Westermann  26
Affiliations
Free article
Multicenter Study

Use of mechanical circulatory support in patients with non-ischaemic cardiogenic shock

Benedikt Schrage et al. Eur J Heart Fail. 2023 Apr.
Free article

Abstract

Aims: Despite its high incidence and mortality risk, there is no evidence-based treatment for non-ischaemic cardiogenic shock (CS). The aim of this study was to evaluate the use of mechanical circulatory support (MCS) for non-ischaemic CS treatment.

Methods and results: In this multicentre, international, retrospective study, data from 890 patients with non-ischaemic CS, defined as CS due to severe de-novo or acute-on-chronic heart failure with no need for urgent revascularization, treated with or without active MCS, were collected. The association between active MCS use and the primary endpoint of 30-day mortality was assessed in a 1:1 propensity-matched cohort. MCS was used in 386 (43%) patients. Patients treated with MCS presented with more severe CS (37% vs. 23% deteriorating CS, 30% vs. 25% in extremis CS) and had a lower left ventricular ejection fraction at baseline (21% vs. 25%). After matching, 267 patients treated with MCS were compared with 267 patients treated without MCS. In the matched cohort, MCS use was associated with a lower 30-day mortality (hazard ratio 0.76, 95% confidence interval 0.59-0.97). This finding was consistent through all tested subgroups except when CS severity was considered, indicating risk reduction especially in patients with deteriorating CS. However, complications occurred more frequently in patients with MCS; e.g. severe bleeding (16.5% vs. 6.4%) and access-site related ischaemia (6.7% vs. 0%).

Conclusion: In patients with non-ischaemic CS, MCS use was associated with lower 30-day mortality as compared to medical therapy only, but also with more complications. Randomized trials are needed to validate these findings.

Keywords: Cardiogenic shock; Mechanical circulatory support; Non-ischaemic cardiogenic shock.

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References

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