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. 2023 Jun;44(5):1135-1142.
doi: 10.1007/s00246-023-03116-x. Epub 2023 Feb 12.

Vortex Formation Time is a Novel Measure for Early Detection of Diastolic Abnormalities in Adolescents with Hypertension

Haripriya Dukkipati  1 , Christine Sethna  1   2 , Kyle Maisel  1 , Monique Jones  3 , Aparna Kulkarni  4   5
Affiliations

Vortex Formation Time is a Novel Measure for Early Detection of Diastolic Abnormalities in Adolescents with Hypertension

Haripriya Dukkipati et al. Pediatr Cardiol. 2023 Jun.

Abstract

Pediatric hypertension (HTN) has demonstrated an upward trend in recent years. Adolescent HTN has been linked to adult HTN, cardiovascular disease, and other health conditions. Thus, it is essential that HTN and its associated cardiac abnormalities be diagnosed and treated early to minimize lifelong adverse effects. In this study, we evaluated whether vortex formation time (VFT), a validated echocardiogram measure of left ventricular diastolic dysfunction, correlated with ambulatory blood pressure monitoring (ABPM) and HTN in adolescents. Echocardiogram data including systolic and diastolic function indices and ABPM data from 2015 to 2022 in adolescents age 13-21 years were analyzed retrospectively. We found that VFT was significantly lower in adolescents with HTN compared to those without HTN (3.69 ± 1.39 vs. 4.50 ± 1.73, p = 0.02). Standard echocardiographic indices of systolic and diastolic function were similar between the two groups, except indexed left atrial volume. Higher overall systolic blood pressure (SBP) (β = - 0.01, CI - 0.02, - 2.2 × 10-3, p = 0.02), mean wake SBP (β = - 0.01, CI - 0.02, - 9.4 × 10-4, p = 0.03), and mean sleep SBP (β = - 0.01, CI - 0.02, - 1.2 × 10-3, p = 0.03) were significantly associated with lower VFT. This study demonstrates that VFT correlates to ABPM data and can be used a novel diagnostic measure in adolescents with HTN.

Keywords: ABPM; Adolescents; Diastolic dysfunction; Echocardiography; Hypertension; Vortex formation time.

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References

    1. Song P, Zhang Y, Yu J, Zha M, Zhu Y, Rahimi K, Rudan I (2019) Global prevalence of hypertension in children: a systematic review and meta-analysis. JAMA Pediatr 173(12):1154. https://doi.org/10.1001/jamapediatrics.2019.3310 - DOI - PubMed - PMC
    1. Khoury M, Urbina EM (2021) Hypertension in adolescents: diagnosis, treatment, and implications. Lancet Child Adolesc Health 5(5):357–366. https://doi.org/10.1016/S2352-4642(20)30344-8 - DOI - PubMed
    1. Guzman-Limon M, Samuels J (2019) Pediatric hypertension. Pediatr Clin North Am 66(1):45–57. https://doi.org/10.1016/j.pcl.2018.09.001 - DOI - PubMed
    1. Flynn JT, Urbina EM, Brady TM, Baker-Smith C, Daniels SR, Hayman LL, Mitsnefes M, Tran A, Zachariah JP, on behalf of the Atherosclerosis, Hypertension, and Obesity in the Young Committee of the American Heart Association Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular Radiology and Intervention; Council on Epidemiology and Prevention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health (2022) Ambulatory blood pressure monitoring in children and adolescents: 2022 update: a scientific statement from the american heart association. Hypertension. https://doi.org/10.1161/HYP.0000000000000215 - DOI - PubMed
    1. Fenster BE, Browning J, Schroeder JD, Schafer M, Podgorski CA, Smyser J, Silveira LJ, Buckner JK, Hertzberg JR (2015) Vorticity is a marker of right ventricular diastolic dysfunction. Am J Physiol-Heart Circ Physiol 309(6):H1087–H1093. https://doi.org/10.1152/ajpheart.00278.2015 - DOI - PubMed

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