Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Stephen Zewinger¹, Jochen Reiser², Vera Jankowski³, Dalia Alansary⁴, Eunsil Hahm², Sarah Triem¹, Mira Klug¹, Stefan J Schunk¹, David Schmit¹, Rafael Kramann^{5

6}, Christina Körbel⁷, Emmanuel Ampofo⁷, Matthias W Laschke⁷, Simina-Ramona Selejan⁸, Anna Paschen¹, Tobias Herter¹, Susanne Gaul⁹, Günther Silbernagel¹⁰, Martina Sester¹¹, Urban Sester¹, Gunter Aßmann¹², Robert Bals¹³, Gerhard Kostner¹⁴, Willi Jahnen-Dechent¹⁵, Michael D Menger⁷, Lucia Rohrer¹⁶, Winfried März^{17

18

19}, Michael Böhm⁸, Joachim Jankowski^{3

20}, Manfred Kopf²¹, Eicke Latz^{22

23

24}, Barbara A Niemeyer⁴, Danilo Fliser¹, Ulrich Laufs^#⁹, Thimoteus Speer^#^{25

26}

Affiliations

¹ Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University, Homburg/Saar, Germany.
² Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
³ Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany.
⁴ Molecular Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg/Saar, Germany.
⁵ Department of Nephrology, University Hospital of the RWTH Aachen, Aachen, Germany.
⁶ Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
⁷ Institute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany.
⁸ Department of Internal Medicine III, Cardiology, Saarland University, Homburg/Saar, Germany.
⁹ Department of Cardiology, University Hospital Leipzig, Leipzig, Germany.
¹⁰ Department of Internal Medicine, Divison of Angiology, Medical University Graz, Graz, Austria.
¹¹ Department of Transplant and Infection Immunology, Saarland University, Homburg/Saar, Germany.
¹² RUB-University Hospital Minden, Minden, Germany.
¹³ Department of Internal Medicine V, Pneumology and Intensive Care Medicine, Saarland University, Homburg/Saar, Germany.
¹⁴ Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University Graz, Graz, Austria.
¹⁵ Biointerface Laboratory, RWTH Aachen University Hospital, Aachen, Germany.
¹⁶ Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland.
¹⁷ Medical Clinic V (Nephrology, Rheumatology, Hypertensiology, Endocrinology, Diabetology), Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
¹⁸ Synlab Academy, Synlab Holding Germany GmbH, Mannheim, Germany.
¹⁹ Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
²⁰ University of Maastricht, CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands.
²¹ Institute of Molecular Health Science, ETH, Zurich, Switzerland.
²² Institute of Innate Immunity, Bonn University, Bonn, Germany.
²³ Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
²⁴ German Center of Neurodegenerative Diseases (DZNE), Bonn, Germany.
²⁵ Department of Internal Medicine 4, Nephrology, Goethe University, Frankfurt/Main, Germany. thimoteus.speer@kgu.de.
²⁶ Else Kroener Fresenius Center for Nephrological Research, Goethe University, Frankfurt/Main, Germany. thimoteus.speer@kgu.de.

^# Contributed equally.

PMID: 36781986
DOI: 10.1038/s41590-023-01424-1

Comment

Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Stephen Zewinger et al. Nat Immunol. 2023 Mar.

. 2023 Mar;24(3):412-413.

doi: 10.1038/s41590-023-01424-1. Epub 2023 Feb 13.

Authors

Affiliations

¹ Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University, Homburg/Saar, Germany.
² Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
³ Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany.
⁴ Molecular Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg/Saar, Germany.
⁵ Department of Nephrology, University Hospital of the RWTH Aachen, Aachen, Germany.
⁶ Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
⁷ Institute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany.
⁸ Department of Internal Medicine III, Cardiology, Saarland University, Homburg/Saar, Germany.
⁹ Department of Cardiology, University Hospital Leipzig, Leipzig, Germany.
¹⁰ Department of Internal Medicine, Divison of Angiology, Medical University Graz, Graz, Austria.
¹¹ Department of Transplant and Infection Immunology, Saarland University, Homburg/Saar, Germany.
¹² RUB-University Hospital Minden, Minden, Germany.
¹³ Department of Internal Medicine V, Pneumology and Intensive Care Medicine, Saarland University, Homburg/Saar, Germany.
¹⁴ Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University Graz, Graz, Austria.
¹⁵ Biointerface Laboratory, RWTH Aachen University Hospital, Aachen, Germany.
¹⁶ Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland.
¹⁷ Medical Clinic V (Nephrology, Rheumatology, Hypertensiology, Endocrinology, Diabetology), Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
¹⁸ Synlab Academy, Synlab Holding Germany GmbH, Mannheim, Germany.
¹⁹ Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
²⁰ University of Maastricht, CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands.
²¹ Institute of Molecular Health Science, ETH, Zurich, Switzerland.
²² Institute of Innate Immunity, Bonn University, Bonn, Germany.
²³ Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
²⁴ German Center of Neurodegenerative Diseases (DZNE), Bonn, Germany.
²⁵ Department of Internal Medicine 4, Nephrology, Goethe University, Frankfurt/Main, Germany. thimoteus.speer@kgu.de.
²⁶ Else Kroener Fresenius Center for Nephrological Research, Goethe University, Frankfurt/Main, Germany. thimoteus.speer@kgu.de.

^# Contributed equally.

PMID: 36781986
DOI: 10.1038/s41590-023-01424-1

No abstract available

PubMed Disclaimer

Comment on

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.
Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Schuster S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T. Zewinger S, et al. Nat Immunol. 2020 Jan;21(1):30-41. doi: 10.1038/s41590-019-0548-1. Epub 2019 Dec 9. Nat Immunol. 2020. PMID: 31819254
Apolipoprotein C3 induces inflammasome activation only in its delipidated form.
Hsu CC, Shao B, Kanter JE, He Y, Vaisar T, Witztum JL, Snell-Bergeon J, McInnes G, Bruse S, Gottesman O, Mullick AE, Bornfeldt KE. Hsu CC, et al. Nat Immunol. 2023 Mar;24(3):408-411. doi: 10.1038/s41590-023-01423-2. Epub 2023 Feb 13. Nat Immunol. 2023. PMID: 36781985 Free PMC article.

References

1. Zewinger, S. et al. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat. Immunol. 21, 30–41 (2020). - DOI - PubMed
1. Hsu, C.-C. et al. Apolipoprotein C3 induces inflammasome activation only in its delipidated form. Nat. Immunol. https://doi.org/10.1038/s41590-023-01424-1 (2023).
1. Zheng, C., Khoo, C., Furtado, J. & Sacks, F. M. Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low-density lipoprotein phenotype. Circulation 121, 1722–1734 (2010). - DOI - PubMed - PMC
1. Mehta, A. & Shapiro, M. D. Apolipoproteins in vascular biology and atherosclerotic disease. Nat. Rev. Cardiol. 19, 168–179 (2022). - DOI - PubMed
1. Tam, S. P., Dory, L. & Rubinstein, D. Fate of apolipoproteins C-1, C-iii, and E during lipolysis of human very low density lipoproteins in vitro. J. Lipid Res. 22, 641–651 (1981). - DOI - PubMed

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Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

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Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

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