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Review
. 2023 Feb;51(2):318-325.
doi: 10.1002/jcu.23412.

Umbilical vein blood flow: State-of-the-art

Affiliations
Free article
Review

Umbilical vein blood flow: State-of-the-art

Moira Barbieri et al. J Clin Ultrasound. 2023 Feb.
Free article

Abstract

Placental blood supply to the fetus can be measured by evaluating the umbilical vein blood flow. Despite its potential application in healthcare, the umbilical vein blood flow volume is still used only in research setting. One of the reasons is a concern regarding its reproducibility, partly due to technology issues. Nowadays, technology improvements make this evaluation accurate and reproducible. The aim of this review is to refresh basic elements of the physiology of umbilical vein blood flow and its analysis. Its evaluation in normal and abnormal fetal growth is also discussed.

Keywords: Doppler ultrasound; fetal growth; fetal growth restriction; umbilical vein blood flow volume.

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References

REFERENCES

    1. Tay J, Masini G, McEniery CM, et al. Uterine and fetal placental Doppler indices are associated with maternal cardiovascular function. Am J Obstet Gynecol. 2019;220(1):96.e1-96.e8. doi:10.1016/j.ajog.2018.09.017
    1. Bellotti M, Pennati G, de Gasperi C, Bozzo M, Battaglia FC, Ferrazzi E. Simultaneous measurements of umbilical venous, fetal hepatic, and ductus venosus blood flow in growth-restricted human fetuses. Am J Obstet Gynecol. 2004;190(5):1347-1358.
    1. Ferrazzi E, Lees C, Acharya G. The controversial role of the ductus venosus in hypoxic human fetuses. Acta Obstet Gynecol Scand. 2019;98(7):823-829. doi:10.1111/aogs.13572
    1. Boito SM, Struijk PC, Ursem NTC, Stijnen T, Wladimiroff JW. Assessment of fetal liver volume and umbilical venous volume flow in pregnancies complicated by insulin-dependent diabetes mellitus. BJOG. 2003;110(11):1007-1013.
    1. Flo K, Wilsgaard T, Acharya G. Longitudinal reference ranges for umbilical vein blood flow at a free loop of the umbilical cord. Ultrasound Obstet Gynecol. 2010;36(5):567-572. doi:10.1002/uog.7730