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. 2023 Feb 13;94(1):e2023034.
doi: 10.23750/abm.v94i1.13738.

Choosing nasal devices: a dilemma in clinical practice

Attilio Varricchio  1 , Francesco Brunese  2 , Ignazio La Mantia  3 , Enrico Ascione  4 , Giorgio Ciprandi  5
Affiliations

Choosing nasal devices: a dilemma in clinical practice

Attilio Varricchio et al. Acta Biomed. .

Abstract

Background and aim: Upper airway diseases are frequent and recognize different etiopathogenetic mechanisms, including infection, inflammation, and allergy. Therefore, topical treatments are preferable in comparison with systemic medications. Several delivery devices are available on the market, including nasal drops, syringes, sprays, nebulizers, and douches. However, it is clinically relevant to know the better way to use it.

Methods: The present experience compared five different devices that were tested: i) a nasal dropper, ii) a standard nasal spray device, iii) a mucosal atomization device with a nozzle tip, iv) a nebulizer device, and v) a nasal douche. Saline solution with methylene blue was the marker to evaluate the intranasal distribution.

Results: The findings showed an apparent difference in area distribution among these delivery devices. Conclusion The present experience showed that doctors should choose the most appropriate device for the current disease in clinical practice.

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Conflict of interest statement

The authors declare that they have no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article.

Figures

Figure 1.
Figure 1.
Frames of Ostio-meatal complex and (OCM) and nasopharynx (NP) for 5 nasal delivery devices: nasal drops, nasal spray, mucosal atomization device, nebulizer device, and nasal douche.
See this image and copyright information in PMC

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