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. 2022 Dec;507(1):283-288.
doi: 10.1134/S1607672922060023. Epub 2023 Feb 14.

Radioprotective Effect of Nanocerium by Irradiation of Mice with Carbon Ions in Medium and Lethal Doses

V E Balakin  1 , O M Rozanova  2 , E N Smirnova  2 , T A Belyakova  3 , N S Strelnikova  1 , A V Smirnov  1 , A G Vasilyeva  4
Affiliations

Radioprotective Effect of Nanocerium by Irradiation of Mice with Carbon Ions in Medium and Lethal Doses

V E Balakin et al. Dokl Biochem Biophys. 2022 Dec.

Abstract

The data of the study of the radioprotective properties of nanocerium (nCeO2) after total irradiation of mice with carbon ions in medium and lethal doses according to the micronucleus test and the criterion of 30-day survival are presented. A significant protective effect of nCeO2 upon irradiation at medium doses was observed at per os administration for 5 days before irradiation (that is, at long-term prophylactic use). Mouse survival data showed no protective effect of per os administration of nCeO2 in contrast to the micronucleus test results. After injections of both nCeO2 and saline solution 24 h before or immediately after irradiation, the radioprotective effect was detected using both methods. The data obtained revealed the dependence of the observed effects on the mode and time of nCeO2 administration, the influence of the solvent, the level of doses and the quality of radiation, as well as demonstrated the possibility of using nanocerium preparations to protect organisms from radiation with high LET values and the importance of further studies of the radioprotective properties of new nanomaterials.

Keywords: carbon ions; cerium nanoparticles; mice; micronucleus; survival.

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References

REFERENCES

    1. Tinganelli, W. and Durante, M., Carbon ion radiobiology, Cancers (Basel), 2020, vol. 12, no. 10, p. 3022. - DOI - PubMed - PMC
    1. Grau, C., Durante, M., Georg, D., et al., Particle therapy in Europe, Mol. Oncol., 2020, vol. 14, no. 7, pp. 1492–1499. - DOI - PubMed - PMC
    1. Seidensaal, K., Mattke, M., Haufe, S., et al., The role of combined ion-beam radiotherapy (cibrt) with protons and carbon ions in a multimodal treatment strategy of inoperable osteosarcoma, Radiother. Oncol., 2021, vol. 159, pp. 8–16. - DOI - PubMed
    1. Thomas, H. and Timmermann, B., Paediatric proton therapy, Br. J. Radiol., 2020, vol. 93, no. 1107, p. 20190601. - DOI - PubMed - PMC
    1. Cortese, F., Klokov, D., Osipov, A., et al., Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization, Oncotarget, 2018, vol. 9, no. 18, pp. 14692–14722. - DOI - PubMed - PMC

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