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Comment
. 2023 Feb 13;41(2):229-231.
doi: 10.1016/j.ccell.2023.01.006.

Paradoxical cancer cell stimulation by IFNγ drives tumor hyperprogression upon checkpoint blockade immunotherapy

Stephane Champiat  1 , Aurelien Marabelle  2
Affiliations
Free article
Comment

Paradoxical cancer cell stimulation by IFNγ drives tumor hyperprogression upon checkpoint blockade immunotherapy

Stephane Champiat et al. Cancer Cell. .
Free article

Abstract

Hyperprogression is a paradoxical cancer acceleration observed in a minority of patients upon immunotherapy. In this issue of Cancer Cell, Li et al demonstrate that hyperprogressive tumors upregulate the Wnt/β-catenin pathway. This activation was subsequent to an oncogenic FGF2-mediated autocrine loop generated by the IFNγ released by CD8+ T cells upon PD-1/PD-L1 blockade.

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Conflict of interest statement

Declaration of interests S.C. and A.M. HPD research projects have been funded by academic grants from Sanofi and Fondation MSD Avenir. S.C. and A.M. have participated to scientific advisory boards and have been investigator of trials sponsored by the following manufacturers of FDA/EMA approved anti-PD(L)1 antibodies: Merck Sharp and Dohme, Bristol Myers Squibb, Astra Zeneca, Roche/Genentech, Sanofi, GSK, Merck Serono, and Pfizer.

Comment on

  • Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy.
    Li G, Choi JE, Kryczek I, Sun Y, Liao P, Li S, Wei S, Grove S, Vatan L, Nelson R, Schaefer G, Allen SG, Sankar K, Fecher LA, Mendiratta-Lala M, Frankel TL, Qin A, Waninger JJ, Tezel A, Alva A, Lao CD, Ramnath N, Cieslik M, Harms PW, Green MD, Chinnaiyan AM, Zou W. Li G, et al. Cancer Cell. 2023 Feb 13;41(2):304-322.e7. doi: 10.1016/j.ccell.2022.12.008. Epub 2023 Jan 12. Cancer Cell. 2023. PMID: 36638784 Free PMC article.

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