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Observational Study
. 2023 Feb 14;23(1):95.
doi: 10.1186/s12877-023-03775-8.

Impact of postoperative intravenous iron therapy on postoperative infections in older patients with severe anaemia after hip fracture surgery

Lene T Hansen  1 , Johannes Riis  2 , Kristian H Kragholm  2   3   4 , Lis K Larsen  5 , Christian Cavallius  5 , Marianne M Mørch  6 , Silas Z Clemmensen  2   5 , Maria L Krogager  4   7 , Dorte Melgaard  8   9
Affiliations
Observational Study

Impact of postoperative intravenous iron therapy on postoperative infections in older patients with severe anaemia after hip fracture surgery

Lene T Hansen et al. BMC Geriatr. .

Abstract

Background: Anaemia is common following hip fracture in ortho-geriatric patients and is associated with postoperative infections.. This study investigated whether intravenous iron supplements reduced the rate of postoperative infections within 30 days postoperatively in older adults after hip fracture surgery.

Methods: This observational study included 198 ortho-geriatric patients July 2018-May 2020. In May 2019 a local guideline was implemented and recommended II therapy on the 3rd postoperative day if haemoglobin concentration was < 6.5 mmol/L after hip fracture surgery.

Results: The patients were divided into four treatment groups: blood transfusion (n = 44), IV iron (n = 69), blood transfusion + IV iron (n = 35) and no treatment (n = 50). The number of patients who had an infection within 30 days was similar in the two time periods (38.8% before vs. 38.9% after systematic I.V. iron supplementation, P = 1.00) and no significant difference according to risk of infection was found between treatment groups.

Conclusion: This study documents no effect of intravenous iron supplements on postoperative infections in older adults after hip fracture surgery.

Trial registration: The study was registered with the Danish Data Protection Authority (2008-58-0028) the 2th of September 2019.

Keywords: Geriatric patients; Intravenous iron; Postoperative anaemia; Postoperative infections; Surgery.

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Conflict of interest statement

No competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of selection of patients for inclusion into the study
See this image and copyright information in PMC

References

    1. Hu F, Jiang C, Shen J, Tang P, Wang Y. Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury. 2012;43(6):676–685. doi: 10.1016/j.injury.2011.05.017. - DOI - PubMed
    1. Kanis JA, Odén A, McCloskey EV, Johansson H, Wahl DA, Cooper C. A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int. 2012;23(9):2239–2256. doi: 10.1007/s00198-012-1964-3. - DOI - PMC - PubMed
    1. Kjørholt KE, Kristensen NR, Prieto-Alhambra D, Johnsen SP, Pedersen AB. Increased risk of mortality after postoperative infection in hip fracture patients. Bone. 2019;127:563–570. doi: 10.1016/j.bone.2019.07.023. - DOI - PubMed
    1. Potter LJ, Doleman B, Moppett IK. A systematic review of pre-operative anaemia and blood transfusion in patients with fractured hips. Anaesthesia. 2015;70(4):483–500. doi: 10.1111/anae.12978. - DOI - PubMed
    1. Hill GE, Frawley WH, Griffith KE, Forestner JE, Minei JP. Allogeneicblood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. J Trauma. 2003;52(5):908–914. doi: 10.1097/01.TA.0000022460.21283.53. - DOI - PubMed

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