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Review
. 2023 Feb 14;23(1):96.
doi: 10.1186/s12903-022-02604-5.

Primary maxillary sinus carcinosarcoma with multidisciplinary management: a case report with 4 years follow-up and literature review

Jiajia Li  1   2   3 , Shaohai Wang  4 , Xiufa Tang  5   6 , Lin Que  5   6 , Wenzhe Han  5   6 , Bo Yu  5   6
Affiliations
Review

Primary maxillary sinus carcinosarcoma with multidisciplinary management: a case report with 4 years follow-up and literature review

Jiajia Li et al. BMC Oral Health. .

Abstract

Background: Primary maxillary sinus carcinosarcoma (CS) is an extremely rare malignant tumor characterized by biphasic histologic components, lack of standardized treatment, high recurrence rate, and poor prognosis. This paper presents a case of primary maxillary sinus CS and its treatment.

Case presentation: A 39-year-old female patient complained of right facial pain and maxillary teeth numbness on March 21, 2018. Computed tomography examination revealed a malignant mass with osteolytic destruction. Preoperative biopsy suggested sarcomatoid carcinoma or CS. A total right maxillectomy under general anesthesia was performed on April 12, 2018. The final staging was T3N0M0 (ACJJ 2019). Postoperative radiotherapy and chemotherapy were performed. On May 26, 2018, the patient received the first cycle of doxorubicin plus ifosfamide. Two days before radiotherapy, the patient received an intra-oral prosthesis. From June 20, 2018, to August 22, 2018, the patient received concurrent chemoradiotherapy: radiotherapy (60 Gy in 30 fractions) and the second cycle of doxorubicin. Then, the patient received four cycles of doxorubicin plus ifosfamide. The patient was followed for 39 months with no evidence of disease.

Conclusion: Using multidisciplinary therapy, clinical-stage T3N0M0 (ACJJ 2019) maxillary sinus CS may achieve a good prognosis.

Keywords: Carcinosarcoma; Chemotherapy; Immunohistochemistry; Maxillary sinus; Prosthetics; Radiotherapy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
A–C Cone-beam computed tomography (CBCT) showing the neoplasm (arrows). D–F The reconstructed bone destruction (arrows)
Fig. 2
Fig. 2
A, B The total maxillectomy and the mass. C The mass was negative for the SS18 (fluorescence in-situ hybridization) gene detection
Fig. 3
Fig. 3
A H&E staining showing the epithelial and mesenchymal components. The mesenchymal component contained well-differentiated osteoid and chondroid tissue. B The scattered epithelial cells were scattered throughout the mesenchymal tissue. C The well-differentiated osteoid tissue. D The chondroid tissue and atypical chondrocytes. Original magnification, 40× (A), 1000× (B–D)
Fig. 4
Fig. 4
A, B The epithelial components CK8(+) and CK18(+) by immunohistochemistry. C, D The mesenchymal component was positive for S100α and vimentin by immunohistochemistry. Original magnification, 400× (A–D)
Fig. 5
Fig. 5
A–F Facial and intra-oral images of the patient without and with the intra-oral prosthesis
See this image and copyright information in PMC

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