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Case Reports
. 2023 Feb 10;10(2):e00978.
doi: 10.14309/crj.0000000000000978. eCollection 2023 Feb.

Colonic Epstein-Barr Virus-Associated Mucocutaneous Ulcer Associated With Ulcerative Colitis

Patrick P Y Chan  1   2 , Mahtab Farzin  1   3 , Priya Acharya  3   4 , Nicholas Viiala  1 , Andrew Gilmore  1   3 , Harry Crane  1 , Christopher Henderson  1   2   3 , Watson Ng  1   2   5 , Astrid Williams  1   2   5 , Susan J Connor  1   2   5
Affiliations
Case Reports

Colonic Epstein-Barr Virus-Associated Mucocutaneous Ulcer Associated With Ulcerative Colitis

Patrick P Y Chan et al. ACG Case Rep J. .

Abstract

Epstein-Barr virus-associated mucocutaneous ulcer is a rare lymphoproliferative disorder that occurs in immunosuppressed states that can develop in the gastrointestinal tract and mimic inflammatory bowel disease or other malignancies. We present the case of a 61-year-old man who presented with concurrent acute severe ulcerative colitis and colonic Epstein-Barr virus-associated mucocutaneous ulcer requiring rituximab therapy and a subtotal colectomy.

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Figures

Figure 1.
Figure 1.
(A) Perianal ulcer, (B) severe ulcerative colitis of the rectum (left), (C) relative sparing of the sigmoid colon (right), and (D) ulcerated descending colon mass with spontaneous bleeding.
Figure 2.
Figure 2.
(A) Hematoxylin and eosin staining of the descending colon biopsy specimen (magnification ×40). Moderate amount of mixture of inflammatory cell infiltrate in the lamina propria with associated cryptitis consistent with active chronic colitis. Associated large monomorphic atypical cells with vesicular nuclei and prominent nucleoli arranged in sheets. (B) EBV-encoded small RNA in situ hybridization (EBER-ISH) probe identified EBV-positive cells (right). EBV, Epstein-Barr virus.
See this image and copyright information in PMC

References

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