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. 2023 Jan 9;8(9):FSO820.
doi: 10.2144/fsoa-2022-0018. eCollection 2022 Oct.

Cancer, diabetes, survival and glycemic control: a large multisite analysis

Nina J Karlin  1 , Heidi E Kosiorek  2 , Patricia M Verona  3 , Kyle E Coppola  4 , Curtiss B Cook  5
Affiliations

Cancer, diabetes, survival and glycemic control: a large multisite analysis

Nina J Karlin et al. Future Sci OA. .

Abstract

Aim: To determine overall survival (OS) and glycemic control in patients with cancer and diabetes.

Materials & methods: Patients of our institution with breast, colon, lung, pancreas and prostate cancer were retrospectively reviewed. OS was compared between matched patients with and without diabetes, and changes in glucose value over time were assessed.

Results: For 3934 patients each with and without diabetes, adjusted analysis showed no difference in OS according to diabetes status (hazard ratio: 1.07; 95% CI: 0.96-1.20). Mean glucose values decreased over time in patients with and without diabetes (p = 0.01).

Conclusion: In this large study of patients with five common cancers, the co-occurrence of diabetes did not affect OS. Cancer did not adversely affect glucose levels.

Keywords: cancer; oncology; outcomes research.

Plain language summary

The aim of this study was to evaluate survival and glucose control in patients with cancer and diabetes at three separate geographic locations in a single health system. From an institutional cancer registry, we identified patients with breast, colon, lung, pancreas and prostate cancers. Patients with and without diabetes were matched by age, sex, cancer type, staging, geographic location and year of cancer diagnosis. In this study, the co-occurrence of diabetes did not affect overall survival. Cancer did not adversely affect glucose levels.

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Figures

Figure 1.
Figure 1.. Glucose control for 1 year after cancer diagnosis.
Data overall (all cancers, all sites) and for individual cancers (aggregate all sites). (A) Hemoglobin A1c (HbA1c) values for patients with diabetes only. (B) Glucose values for patients with and without diabetes.
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention. National Diabetes Statistics Report 2020 (2020). http://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-stati...
    1. Centers for Disease Control and Prevention. United States Cancer Statistics: prevalence (2021). https://gis.cdc.gov/Cancer/USCS/#/Prevalence/
    1. Centers for Disease Control and Prevention. Changes Over Time: All Types of Cancer (2021). https://gis.cdc.gov/Cancer/USCS/#/Trends/
    1. Habib SL, Rojna M. Diabetes and risk of cancer. ISRN Oncol. 2013, 583786 (2013). - PMC - PubMed

    2. •• Summarizes epidemiologic association studies of diabetes and cancer.

    1. Karlin NJ, Dueck AC, Cook CB. Cancer with diabetes: prevalence, metabolic control, and survival in an academic oncology practice. Endocr. Pract. 18(6), 898–905 (2012). - PubMed

    2. • Shows that diabetes was common, glycemic control often was suboptimal and survival varied by cancer type.

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