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Comment
. 2023 May 2;192(1):15-16.
doi: 10.1093/plphys/kiad090.

Metal health: PATELLIN2 reduces iron-induced toxicity in Arabidopsis

Stefanie Wege  1 , José Manuel Ugalde  2   3
Affiliations
Comment

Metal health: PATELLIN2 reduces iron-induced toxicity in Arabidopsis

Stefanie Wege et al. Plant Physiol. .
No abstract available

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Conflict of interest statement

Conflict of interest statement. The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Model of PATL2-mediated reduction of Fe-induced oxidative damage. Apoplastic Ferric Fe (Fe3+) is reduced by membrane-bound FERRIC REDUCTION REDUCTASE 2 (FRO2) to ferrous Fe (Fe2+), which is transported to the cytosol via IRT1. Excess Fe2+ can interact with ROS leading to oxidative damage by promoting lipid peroxidation. The N-terminus of PATL2 (CTN-SEC14-GOLD) interacts with the variable region of IRT1 (IRT1vr), and its SEC14 domain binds α-tocopherol in vitro. The current model hypothesizes that PATL2 might make the antioxidant α-tocopherol available where lipid peroxidation is occurring, alleviating oxidative damage. Further work will be required to confirm if α-tocopherol or another component is binding to PATL2 in vivo (Modified figure from Hornbergs et al. (2023) made by J.M.U. using Affinity Designer 2 Version 2.0.3).
See this image and copyright information in PMC

Comment on

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