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Comment
. 2023 Apr;101(4):281-284.
doi: 10.1111/imcb.12630. Epub 2023 Mar 9.

A dual role of microbiota type 17 immunity in tissue repair and pain

Paul J Austin  1 , Jackson F Karrasch  1 , Jayden A O'Brien  1
Affiliations
Comment

A dual role of microbiota type 17 immunity in tissue repair and pain

Paul J Austin et al. Immunol Cell Biol. 2023 Apr.

Abstract

In this commentary, we discuss the findings of Enamorado et al. who have, for the first time, demonstrated that immunity to the microbiota enhances repair of cutaneous sensory nerves and epithelial tissues following skin injury. Commensal-specific IL-17 producing CD4+ T helper cells have direct contact with injured sensory neurons, inducing multiple epithelial and neuronal repair genes. We speculate that an altered balance of T cell populations in the skin of people with chronic neuropathic pain may contribute to a reduction in neuronal repair and the consequent decease in intraepidermal nerve fibre density and persistent pain.

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Comment on

  • Immunity to the microbiota promotes sensory neuron regeneration.
    Enamorado M, Kulalert W, Han SJ, Rao I, Delaleu J, Link VM, Yong D, Smelkinson M, Gil L, Nakajima S, Linehan JL, Bouladoux N, Wlaschin J, Kabat J, Kamenyeva O, Deng L, Gribonika I, Chesler AT, Chiu IM, Le Pichon CE, Belkaid Y. Enamorado M, et al. Cell. 2023 Feb 2;186(3):607-620.e17. doi: 10.1016/j.cell.2022.12.037. Epub 2023 Jan 13. Cell. 2023. PMID: 36640762 Free PMC article.

References

REFERENCES

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