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Review
. 2023 Mar;12(5):5676-5687.
doi: 10.1002/cam4.5407. Epub 2023 Feb 15.

Autophagy and its role in osteosarcoma

Biao Ning  1   2   3 , Yixin Liu  1   2   3 , Tianhe Huang  1   2   3 , Yongchang Wei  1   2   3
Affiliations
Review

Autophagy and its role in osteosarcoma

Biao Ning et al. Cancer Med. 2023 Mar.

Abstract

Osteosarcoma (OS) is the most common bone malignancy and preferably occurs in children and adolescents. Despite significant advances in surgery and chemotherapy for OS over the past few years, overall survival rates of OS have reached a bottleneck. Thus, extensive researches aimed at developing new therapeutic targets for OS are urgently needed. Autophagy, a conserved process which allows cells to recycle altered or unused organelles and cellular components, has been proven to play a critical role in multiple biological processes in OS. In this article, we summarized the association between autophagy and proliferation, metastasis, chemotherapy, radiotherapy, and immunotherapy of OS, revealing that autophagy-related genes and pathways could serve as potential targets for OS therapy.

Keywords: autophagy; chemotherapy; immunotherapy; osteosarcoma; progression; radiotherapy.

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Conflict of interest statement

All authors acknowledge that there is no conflict of interest in this review.

Figures

FIGURE 1
FIGURE 1
Autophagy involved in OS progression and treatment.
FIGURE 2
FIGURE 2
The main processes of autophagy and their molecular mechanisms.
FIGURE 3
FIGURE 3
Autophagic pathways common in OS.
See this image and copyright information in PMC

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