Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 May;50(5):415-419.
doi: 10.1111/cup.14409. Epub 2023 Mar 3.

Imatinib-induced lichen planus and lichenoid drug eruption: A report of three cases

Y Almheirat  1 , S Bouabdalla  1 , H Daflaoui  1 , N Zizi  1   2 , S Dikhaye  1   2
Affiliations
Case Reports

Imatinib-induced lichen planus and lichenoid drug eruption: A report of three cases

Y Almheirat et al. J Cutan Pathol. 2023 May.

Abstract

Cutaneous adverse effects of imatinib are common and well documented in the literature. However, imatinib-induced lichen planus is an uncommon side effect with only four reported cases. In addition, reactivation of hepatitis B is an extremely rare association. We report two cases of imatinib-induced lichen planus, one of which is associated with hepatitis B reactivation, and one case of lichenoid eruption caused by imatinib. The aim of our report is to make physicians aware of this rare association between lichen planus and imatinib. We also recommend screening for hepatitis B virus before starting treatment with imatinib to avoid serious complications.

Keywords: hepatitis B; imatinib; lichen planus.

PubMed Disclaimer

References

REFERENCES

    1. Reyes-Habito CM, Roh EK. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer: part II. Targeted therapy. J Am Acad Dermatol. 2014;71(2):217.e1-217.e11. doi:10.1016/j.jaad.2014.04.013
    1. Frioui R, Ouni NEI, Mokni S, et al. Un cas de lichen plan inversé induit par l'imatinib. Rev Med Interne. 2021;42:A417. doi:10.1016/j.revmed.2021.10.136
    1. Inayat F, Song F, Ali NS, et al. Hepatitis B virus reactivation following imatinib therapy: a comparative review of 9 cases. J Oncol Pharm Pract. 2019;25(6):1500-1508. doi:10.1177/1078155218790337
    1. Lei T, Tan F, Hou Z, Liu P, Zhao X, Liu H. Hepatitis B virus reactivation in gastrointestinal stromal tumor patients treated with imatinib. Front Oncol. 2021;10:596500. doi:10.3389/fonc.2020.596500
    1. Chen CB, Wu MY, Ng CY, et al. Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies. Cancer Manag Res. 2018;10:1259-1273. doi:10.2147/CMAR.S163391

Publication types

MeSH terms

Substances

LinkOut - more resources