"KEAP"ing Alveolar Macrophage Mitochondria Content in Chronic Obstructive Pulmonary Disease

Suzanne M Cloonan^{1

2}

Affiliations

Editorial

Suzanne M Cloonan. Am J Respir Crit Care Med. 2023.

. 2023 Apr 15;207(8):962-964.

doi: 10.1164/rccm.202302-0200ED.

Suzanne M Cloonan^{1

2}

No abstract available

Comment on

NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease.
Ryan EM, Sadiku P, Coelho P, Watts ER, Zhang A, Howden AJM, Sanchez-Garcia MA, Bewley M, Cole J, McHugh BJ, Vermaelen W, Ghesquiere B, Carmeliet P, Rodriguez Blanco G, Von Kriegsheim A, Sanchez Y, Rumsey W, Callahan JF, Cooper G, Parkinson N, Baillie K, Cantrell DA, McCafferty J, Choudhury G, Singh D, Dockrell DH, Whyte MKB, Walmsley SR. Ryan EM, et al. Am J Respir Crit Care Med. 2023 Apr 15;207(8):998-1011. doi: 10.1164/rccm.202203-0482OC. Am J Respir Crit Care Med. 2023. PMID: 36724365 Free PMC article.

1. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med . 2004;350:2645–2653. - PubMed
1. Finkelstein R, Fraser RS, Ghezzo H, Cosio MG. Alveolar inflammation and its relation to emphysema in smokers. Am J Respir Crit Care Med . 1995;152:1666–1672. - PubMed
1. Guilliams M, De Kleer I, Henri S, Post S, Vanhoutte L, De Prijck S, et al. Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. J Exp Med . 2013;210:1977–1992. - PMC - PubMed
1. Baßler K, Fujii W, Kapellos TS, Dudkin E, Reusch N, Horne A, et al. Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation. Front Immunol . 2022;13:917232. - PMC - PubMed
1. Qureshi H, Sharafkhaneh A, Hanania NA. Chronic obstructive pulmonary disease exacerbations: latest evidence and clinical implications. Ther Adv Chronic Dis . 2014;5:212–227. - PMC - PubMed