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. 2023 Apr 1;8(4):406-408.
doi: 10.1001/jamacardio.2022.5601.

High-Sensitivity Troponin T and I Among Pregnant Women in the US-The National Health and Nutrition Examination Survey, 1999-2004

Anum S Minhas  1   2 , Justin B Echouffo-Tcheugui  3 , Sui Zhang  4 , Chiadi E Ndumele  1   2   4 , J William McEvoy  2   5 , Robert Christenson  6 , Elizabeth Selvin  4
Affiliations

High-Sensitivity Troponin T and I Among Pregnant Women in the US-The National Health and Nutrition Examination Survey, 1999-2004

Anum S Minhas et al. JAMA Cardiol. .
No abstract available

Plain language summary

This cross-sectional study investigates the expected physiologic concentrations of high-sensitivity cardiac troponin in normal pregnancy.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Minhas reported receiving grants from the National Center for Advancing Translational Sciences during the conduct of the study. Dr Christenson reported receiving grants from Foundation of the National Institutes of Health; consulting fees from Siemens Healthineers, Roche Diagnostics, Beckman Coulter, Becton Dickinson, Sphingotech, and Quidel outside the submitted work; and being editor in chief of The Journal of Applied Laboratory Medicine. Dr Selvin reported receiving grants from Foundation for the National Institutes of Health and the National Institutes of Health. Reagents for the high-sensitivity cardiac troponin assays were donated by the manufacturers. No other disclosures were reported.

Figures

Figure.
Figure.. Distribution of High-Sensitivity Cardiac Troponin (hs-cTn) Among Nonpregnant and Pregnant Women by Trimester, Aged 20 to 40 Years, National Health and Nutrition Examination Survey (NHANES), 1999-2004
Cardiac troponin distribution of nonpregnant and pregnant women aged 20 to 40 years from the NHANES. The following assays were performed: hs-cTn T (Roche) (A); hs-cTn I (Abbott) (B); hs-cTn I (Siemens) (C); and hs-cTn I (Ortho) (D).
See this image and copyright information in PMC

Comment in

  • Troponins and Pregnancy-Reply.
    Minhas AS, Selvin E. Minhas AS, et al. JAMA Cardiol. 2023 Sep 1;8(9):890-891. doi: 10.1001/jamacardio.2023.2112. JAMA Cardiol. 2023. PMID: 37494021 No abstract available.
  • Troponins and Pregnancy.
    Furenäs E, Dellborg M. Furenäs E, et al. JAMA Cardiol. 2023 Sep 1;8(9):890. doi: 10.1001/jamacardio.2023.2109. JAMA Cardiol. 2023. PMID: 37494028 No abstract available.

References

    1. Sanghavi M, Rutherford JD. Cardiovascular physiology of pregnancy. Circulation. 2014;130(12):1003-1008. doi: 10.1161/CIRCULATIONAHA.114.009029 - DOI - PubMed
    1. Umazume T, Yamada T, Yamada S, et al. Morphofunctional cardiac changes in pregnant women: associations with biomarkers. Open Heart. 2018;5(2):e000850. doi: 10.1136/openhrt-2018-000850 - DOI - PMC - PubMed
    1. Creanga AA, Syverson C, Seed K, Callaghan WM. Pregnancy-related mortality in the US, 2011-2013. Obstet Gynecol. 2017;130(2):366-373. doi: 10.1097/AOG.0000000000002114 - DOI - PMC - PubMed
    1. Sarma AA, Aggarwal NR, Briller JE, et al. The utilization and interpretation of cardiac biomarkers during pregnancy. JACC: Adv. 2022;1(3):1-13. doi: 10.1016/j.jacadv.2022.100064 - DOI - PMC - PubMed
    1. Johnson CL, Paulose-Ram R, Ogden CL, et al. National Health and Nutrition Examination Survey: analytic guidelines, 1999-2010. Vital Health Stat 2. 2013;(161):1-24. - PubMed

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