Biophysics of biomolecular condensates

doi:10.1016/j.bpj.2023.02.002

Editorial

. 2023 Mar 7;122(5):737-740.

doi: 10.1016/j.bpj.2023.02.002. Epub 2023 Feb 14.

Biophysics of biomolecular condensates

Ashish Joshi¹, Samrat Mukhopadhyay²

Affiliations

¹ Centre for Protein Science, Design and Engineering, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India.
² Centre for Protein Science, Design and Engineering, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India. Electronic address: mukhopadhyay@iisermohali.ac.in.

PMID: 36791720
PMCID: PMC10027443
DOI: 10.1016/j.bpj.2023.02.002

Editorial

Biophysics of biomolecular condensates

Ashish Joshi et al. Biophys J. 2023.

. 2023 Mar 7;122(5):737-740.

doi: 10.1016/j.bpj.2023.02.002. Epub 2023 Feb 14.

Authors

Ashish Joshi¹, Samrat Mukhopadhyay²

Affiliations

¹ Centre for Protein Science, Design and Engineering, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India.
² Centre for Protein Science, Design and Engineering, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India. Electronic address: mukhopadhyay@iisermohali.ac.in.

PMID: 36791720
PMCID: PMC10027443
DOI: 10.1016/j.bpj.2023.02.002

Abstract

The formation of biomolecular condensates has emerged as a new biophysical principle for subcellular compartmentalization within cells to facilitate the spatiotemporal regulation of a multitude of complex biomolecular reactions. In this Research Highlight, we summarize the findings that were published in Biophysical Journal during the past two years (2021 and 2022). These papers provided biophysical insights into the formation of biomolecular condensates via phase separation of proteins with or without nucleic acids.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

References

1. Kilgore H.R., Young R.A. Learning the chemical grammar of biomolecular condensates. Nat. Chem. Biol. 2022;18:1298–1306. - PMC - PubMed
1. Alberti S., Hyman A.A. Hyman, Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing. Nat. Rev. Mol. Cell Biol. 2021;22:196–213. - PubMed
1. Lyon A.S., Peeples W.B., Rosen M.K. A framework for understanding the functions of biomolecular condensates across scales. Nat. Rev. Mol. Cell Biol. 2021;22:215–235. - PMC - PubMed
1. Mittag T., Pappu R.V. A conceptual framework for understanding phase separation and addressing open questions and challenges. Mol. Cell. 2022;82:2201–2214. - PMC - PubMed
1. Fuxreiter M., Vendruscolo M. Generic nature of the condensed states of proteins. Nat. Cell Biol. 2021;23:587–594. - PubMed

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[1] Kilgore H.R., Young R.A. Learning the chemical grammar of biomolecular condensates. Nat. Chem. Biol. 2022;18:1298–1306. - PMC - PubMed

[2] Kilgore H.R., Young R.A. Learning the chemical grammar of biomolecular condensates. Nat. Chem. Biol. 2022;18:1298–1306. - PMC - PubMed

[3] Alberti S., Hyman A.A. Hyman, Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing. Nat. Rev. Mol. Cell Biol. 2021;22:196–213. - PubMed

[4] Alberti S., Hyman A.A. Hyman, Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing. Nat. Rev. Mol. Cell Biol. 2021;22:196–213. - PubMed

[5] Lyon A.S., Peeples W.B., Rosen M.K. A framework for understanding the functions of biomolecular condensates across scales. Nat. Rev. Mol. Cell Biol. 2021;22:215–235. - PMC - PubMed

[6] Lyon A.S., Peeples W.B., Rosen M.K. A framework for understanding the functions of biomolecular condensates across scales. Nat. Rev. Mol. Cell Biol. 2021;22:215–235. - PMC - PubMed

[7] Mittag T., Pappu R.V. A conceptual framework for understanding phase separation and addressing open questions and challenges. Mol. Cell. 2022;82:2201–2214. - PMC - PubMed

[8] Mittag T., Pappu R.V. A conceptual framework for understanding phase separation and addressing open questions and challenges. Mol. Cell. 2022;82:2201–2214. - PMC - PubMed

[9] Fuxreiter M., Vendruscolo M. Generic nature of the condensed states of proteins. Nat. Cell Biol. 2021;23:587–594. - PubMed

[10] Fuxreiter M., Vendruscolo M. Generic nature of the condensed states of proteins. Nat. Cell Biol. 2021;23:587–594. - PubMed

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Biophysics of biomolecular condensates

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Biophysics of biomolecular condensates

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Abstract

Conflict of interest statement

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