Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Mar 7;122(5):737-740.
doi: 10.1016/j.bpj.2023.02.002. Epub 2023 Feb 14.

Biophysics of biomolecular condensates

Ashish Joshi  1 , Samrat Mukhopadhyay  2
Affiliations
Editorial

Biophysics of biomolecular condensates

Ashish Joshi et al. Biophys J. .

Abstract

The formation of biomolecular condensates has emerged as a new biophysical principle for subcellular compartmentalization within cells to facilitate the spatiotemporal regulation of a multitude of complex biomolecular reactions. In this Research Highlight, we summarize the findings that were published in Biophysical Journal during the past two years (2021 and 2022). These papers provided biophysical insights into the formation of biomolecular condensates via phase separation of proteins with or without nucleic acids.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

References

    1. Kilgore H.R., Young R.A. Learning the chemical grammar of biomolecular condensates. Nat. Chem. Biol. 2022;18:1298–1306. - PMC - PubMed
    1. Alberti S., Hyman A.A. Hyman, Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing. Nat. Rev. Mol. Cell Biol. 2021;22:196–213. - PubMed
    1. Lyon A.S., Peeples W.B., Rosen M.K. A framework for understanding the functions of biomolecular condensates across scales. Nat. Rev. Mol. Cell Biol. 2021;22:215–235. - PMC - PubMed
    1. Mittag T., Pappu R.V. A conceptual framework for understanding phase separation and addressing open questions and challenges. Mol. Cell. 2022;82:2201–2214. - PMC - PubMed
    1. Fuxreiter M., Vendruscolo M. Generic nature of the condensed states of proteins. Nat. Cell Biol. 2021;23:587–594. - PubMed

Publication types

LinkOut - more resources