Spontaneous regression in chronic lymphocytic leukaemia. Clinical features of 50 cases from the ERIC registry and review of the literature

Affiliations

¹ Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
² Department of Hematology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
³ Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
⁴ Danish Cancer Society Research Center, Copenhagen, Denmark.
⁵ Department of Haematology, University Hospitals Dorset, Bournemouth, UK.
⁶ Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua, Italy.
⁷ Department of Hematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
⁸ IRCCS, Pavia, Italy.
⁹ Hematology Unit AO of Cosenza, Cosenza, Italy.
¹⁰ Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
¹¹ National Center for Cancer Care and Research, Doha, Qatar.
¹² Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
¹³ Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy.
¹⁴ Hematology, Medicine Clinic, Falun Hospital, Falun, Sweden.
¹⁵ Department of Hematology, Uppsala University Hospital, Uppsala, Sweden.
¹⁶ Department of Molecular Medicine, Sapienza University, Rome, Italy.

Review

Ilaria Del Giudice et al. Br J Haematol. 2023 Apr.

. 2023 Apr;201(2):353-356.

doi: 10.1111/bjh.18696. Epub 2023 Feb 15.

¹ Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
² Department of Hematology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
³ Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
⁴ Danish Cancer Society Research Center, Copenhagen, Denmark.
⁵ Department of Haematology, University Hospitals Dorset, Bournemouth, UK.
⁶ Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua, Italy.
⁷ Department of Hematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
⁸ IRCCS, Pavia, Italy.
⁹ Hematology Unit AO of Cosenza, Cosenza, Italy.
¹⁰ Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
¹¹ National Center for Cancer Care and Research, Doha, Qatar.
¹² Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
¹³ Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy.
¹⁴ Hematology, Medicine Clinic, Falun Hospital, Falun, Sweden.
¹⁵ Department of Hematology, Uppsala University Hospital, Uppsala, Sweden.
¹⁶ Department of Molecular Medicine, Sapienza University, Rome, Italy.

No abstract available

References

1. Ribera JM, Viñolas N, Urbano-Ispizua A, Gallart T, Montserrat E, Rozman C. "Spontaneous" complete remissions in chronic lymphocytic leukemia: report of three cases and review of the literature. Blood Cells. 1987;12(2):471-83.
1. Schmidt HH, Sill H, Eibl M, Beham-Schmid C, Höfler G, Haas OA, et al. Hodgkin's disease developing after spontaneous remission of chronic lymphocytic leukemia. Ann Hematol. 1995;71(5):247-52.
1. Nakhla PS, Butera JN, Treaba DO, Beham-Schmid C, Höfler G, Haas OA, et al. Spontaneous regression of chronic lymphocytic leukemia to a monoclonal B-lymphocytosis or to a normal phenotype. Leuk Lymphoma. 2013;54(8):1647-51.
1. Del Giudice I, Chiaretti S, Tavolaro S, De Propris MS, Maggio R, Mancini F, et al. Spontaneous regression of chronic lymphocytic leukemia: clinical and biologic features of 9 cases. Blood. 2009;114(3):638-46.
1. Kwok M, Oldreive C, Rawstron AC, Goel A, Papatzikas G, Jones RE, et al. Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL. Blood. 2020;135(6):411-28.