Biomedical materials for wound dressing: recent advances and applications

Abstract

Wound healing is vital to maintain the physiological functions of the skin. The most common treatment is the use of a dressing to cover the wound and reduce infection risk and the rate of secondary injuries. Modern wound dressings have been the top priority choice for healing various types of wounds owing to their outstanding biocompatibility and biodegradability. In addition, they also maintain temperature and a moist environment, aid in pain relief, and improve hypoxic environments to stimulate wound healing. Due to the different types of wounds, as well as the variety of advanced wound dressing products, this review will provide information on the clinical characteristics of the wound, the properties of common modern dressings, and the in vitro, in vivo as well as the clinical trials on their effectiveness. The most popular types commonly used in producing modern dressings are hydrogels, hydrocolloids, alginates, foams, and films. In addition, the review also presents the polymer materials for dressing applications as well as the trend of developing these current modern dressings to maximize their function and create ideal dressings. The last is the discussion about dressing selection in wound treatment and an estimate of the current development tendency of new materials for wound healing dressings.

Fig. 1. Cell responses during five stages of acute wound healing.

Fig. 2. Wound dressing classification.

Fig. 3. Two layers structure of hydrocolloid dressings.

Fig. 4. Alginate dressing and chemical structure of sodium alginate.

Fig. 5. Structure of hydrogel dressings.

Fig. 6. Three layers structure of foam dressings.

Fig. 7. Simple illustrated structure of semi-interpenetrating network.