Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan 30:11:1117368.
doi: 10.3389/fcell.2023.1117368. eCollection 2023.

Neuroimmune cardiovascular interfaces in atherosclerosis

Sarajo K Mohanta  1   2 , Changjun Yin  1   2   3 , Christian Weber  1   2   4 , Andreas J R Habenicht  1   2
Affiliations
Review

Neuroimmune cardiovascular interfaces in atherosclerosis

Sarajo K Mohanta et al. Front Cell Dev Biol. .

Abstract

Two pairs of biological systems acting over long distances have recently been defined as major participants in the regulation of physiological and pathological tissue reactions: i) the nervous and vascular systems form various blood-brain barriers and control axon growth and angiogenesis; and ii) the nervous and immune systems emerge as key players to direct immune responses and maintain blood vessel integrity. The two pairs have been explored by investigators in relatively independent research areas giving rise to the concepts of the rapidly expanding topics of the neurovascular link and neuroimmunology, respectively. Our recent studies on atherosclerosis led us to consider a more inclusive approach by conceptualizing and combining principles of the neurovascular link and neuroimmunology: we propose that the nervous system, the immune system and the cardiovascular system undergo complex crosstalks in tripartite rather than bipartite interactions to form neuroimmune cardiovascular interfaces (NICIs).

Keywords: adventitia; artery tertiary lymphoid organs; atherosclerosis; neuroimmune cardiovascular interface; neuroimmunology; neurovascular link.

PubMed Disclaimer

Conflict of interest statement

SM, CY, and AH are owners of Easemedcontrol R&D and Co KG. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Choreography of an adventitia NICI in advanced murine atherosclerosis. Recent studies into a possible innervation of the adventitia by the axons of the peripheral nervous system revealed that both the sensory and the sympathetic nervous systems undergo marked restructuring in artery segments afflicted with atherosclerosis in murine models of atherosclerosis and human adventitia segments adjacent to plaques in multiple territories of the arterial tree [adopted from (Mohanta et al., 2022)].
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Akhavanpoor M., Gleissner C. A., Akhavanpoor H., Lasitschka F., Doesch A. O., Katus H. A., et al. (2018). Adventitial tertiary lymphoid organ classification in human atherosclerosis. Cardiovasc Pathol. 32, 8–14. 10.1016/j.carpath.2017.08.002 - DOI - PubMed
    1. Anderson D. J., Adolphs R. (2014). A framework for studying emotions across species. Cell 157, 187–200. 10.1016/j.cell.2014.03.003 - DOI - PMC - PubMed
    1. Andersson U., Tracey K. J. (2012). Reflex principles of immunological homeostasis. Annu. Rev. Immunol. 30, 313–335. 10.1146/annurev-immunol-020711-075015 - DOI - PMC - PubMed
    1. Brea D., Veiga-Fernandes H. (2022). Inflammation in the gut is encoded by neurons in the brain. Nature 602, 217–218. 10.1038/d41586-021-03802-x - DOI - PubMed
    1. Brunet I., Gordon E., Han J., Cristofaro B., Broqueres-You D., Liu C., et al. (2014). Netrin-1 controls sympathetic arterial innervation. J. Clin. investigation 124, 3230–3240. 10.1172/JCI75181 - DOI - PMC - PubMed

LinkOut - more resources