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Review
. 2023 Jan 12;15(1):e33678.
doi: 10.7759/cureus.33678. eCollection 2023 Jan.

Intranasal Mupirocin to Reduce Surgical Site Infection Post Cardiac Surgery: A Review of the Literature

Jessy Nellipudi  1 , Caleb Stone  2
Affiliations
Review

Intranasal Mupirocin to Reduce Surgical Site Infection Post Cardiac Surgery: A Review of the Literature

Jessy Nellipudi et al. Cureus. .

Abstract

Sternal wound infections after cardiac surgery are associated with high rates of morbidity and mortality. One of the known risk factors of sternal wound infection is Staphylococcus aureus colonisation. Intranasal mupirocin decolonisation therapy implemented pre-operatively appears to be an effective preventative measure in reducing sternal wound infections post-cardiac surgery. Therefore, the main aim of this review is to evaluate the current literature regarding the use of intranasal mupirocin before cardiac surgery and its impact on sternal wound infection rates.

Keywords: cardiac surgery; mupirocin; prophylactic antibiotics; staphylococcus aureu; sternal wound infection.

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Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. Surgical wound infection rates by wound class, operative procedure, and patient risk index. Culver DH, Horan TC, Gaynes RP, et al. Am J Med. 1991;91:152–157. - PubMed
    1. Epidemiological surveillance of surgical site infection and its risk factors in cardiac surgery: a prospective cohort study. Figuerola-Tejerina A, Rodríguez-Caravaca G, Bustamante-Munguira J, María San Román-Montero J, Durán-Poveda M. Rev Esp Cardiol (Engl Ed) 2016;69:842–848. - PubMed
    1. Surveillance and epidemiology of surgical site infections after cardiothoracic surgery in The Netherlands, 2002-2007. Manniën J, Wille JC, Kloek JJ, van Benthem BH. J Thorac Cardiovasc Surg. 2011;141:899–904. - PubMed
    1. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. National Nosocomial Infections Surveillance System. https://pubmed.ncbi.nlm.nih.gov/15573054/ Am J Infect Control. 2004;32:470–485. - PubMed
    1. Risk factors for mediastinitis after cardiac surgery. Abboud CS, Wey SB, Baltar VT. Ann Thorac Surg. 2004;77:676–683. - PubMed

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