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Review
. 2023 Jan 30:11:1092895.
doi: 10.3389/fpubh.2023.1092895. eCollection 2023.

Expert-opinion-based guidance for the care of children with lysosomal storage diseases during the COVID-19 pandemic: An experience-based Turkey perspective

Abdurrahman Akgun  1 , Gulden Gokcay  2 , Neslihan Onenli Mungan  3 , Hatice Serap Sivri  4 , Hasan Tezer  5 , Cigdem Aktuglu Zeybek  6 , Fatih Ezgu  7
Affiliations
Review

Expert-opinion-based guidance for the care of children with lysosomal storage diseases during the COVID-19 pandemic: An experience-based Turkey perspective

Abdurrahman Akgun et al. Front Public Health. .

Abstract

This expert-opinion-based document was prepared by a group of specialists in pediatric inherited metabolic diseases and infectious diseases including administrative board members of Turkish Society for Pediatric Nutrition and Metabolism to provide guidance for the care of children with lysosomal storage disorders (LSDs) during the COVID-19 pandemic in Turkey. The experts reached consensus on key areas of focus regarding COVID-19-based risk status in relation to intersecting immune-inflammatory mechanisms and disease patterns in children with LSDs, diagnostic virus testing, particularly preventive measures and priorities during the pandemic, routine screening and diagnostic interventions for LSDs, psychological and socioeconomic impact of confinement measures and quarantines and optimal practice patterns in managing LSDs and/or COVID-19. The participating experts agreed on the intersecting characteristics of immune-inflammatory mechanisms, end-organ damage and prognostic biomarkers in LSD and COVID-19 populations, emphasizing the likelihood of enhanced clinical care when their interaction is clarified via further studies addressing certain aspects related to immunity, lysosomal dysfunction and disease pathogenesis. In the context of the current global COVID-19 pandemic, this expert-opinion-based document provides guidance for the care of children with LSDs during the COVID-19 pandemic based on the recent experience in Turkey.

Keywords: COVID-19 pandemic; expert opinion; immune-inflammatory mechanisms; lysosomal storage diseases; specialized care.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Antiviral response according to disease severity and time in COVID-19. Adapted from Jamilloux et al. (25).
Figure 2
Figure 2
Immunomodulatory treatments in Pompe disease. Adapted from Kishnani et al. (53).
See this image and copyright information in PMC

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