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. 1978 Dec 18;45(2):209-13.
doi: 10.1007/BF00286965.

The testis as a secretory organ for H-Y antigen

U Müller, J W Siebers, M T Zenzes, U Wolf

The testis as a secretory organ for H-Y antigen

U Müller et al. Hum Genet. .

Abstract

After cultivation of dissociated rat testicular tissues, H-Y antigen is detectable in the medium; this is not the case if nongonadal male tissues are incubated. Release of H-Y antigen by testis cells is inhibited by the addition of cycloheximide. All tissues still type H-Y positive after culture. It is assumed that the testis actively secretes H-Y antigen. This assumption is supported by the finding that the amount of H-Y antigen in the epididymal fluid increases with the age of the animals.

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